补充ω-3 脂肪酸后血清脑源性神经营养因子的变化：系统评价和 Meta 回归分析。
Changes in serum brain-derived neurotrophic factor following supplementation of omega 3 fatty acids: A systematic review and Meta-Regression analysis.
机构信息
Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran.
Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran.
出版信息
Clin Nutr ESPEN. 2023 Aug;56:207-214. doi: 10.1016/j.clnesp.2023.05.019. Epub 2023 Jun 7.
BACKGROUND & AIMS: This study aimed to comprehensively investigate the effects of omega 3 supplementation on BDNF.
METHODS
Original databases were searched using standard keywords to identify all controlled trials that investigating the BDNF effects of omega 3 supplementation. Pooled weighted mean difference and 95% confidence intervals were achieved by random-effects model analysis for the best estimation of outcomes.
RESULTS
According to the results of a random-effects meta-analysis, omega 3 supplementation significantly raised BDNF levels compared to the control group (pooled WMD of 1.01 μmol/L; 95% confidence interval [CI] 0.35 to 1.67; P = 0.003) and this increase was even more pronounced for interventions >10 weeks and doses ≤1500 mg/day. Additionally, in individuals under 50 years of age, a greater increase in the effects of omega-3 supplements on this brain factor was observed.
CONCLUSIONS
The present comprehensive review and meta-regression analysis generally showed that omega-3 supplementation can statistically significantly increase BDNF levels.
背景与目的
本研究旨在全面研究 ω-3 补充剂对脑源性神经营养因子（BDNF）的影响。
方法
使用标准关键字搜索原始数据库，以确定所有研究 ω-3 补充剂对 BDNF 影响的对照试验。采用随机效应模型分析得出合并加权均数差值和 95%置信区间，以最佳估计结果。
结果
根据随机效应荟萃分析的结果，与对照组相比，ω-3 补充剂可显著提高 BDNF 水平（合并加权均数差值为 1.01 μmol/L；95%置信区间为 0.35 至 1.67；P = 0.003），对于干预时间>10 周和剂量≤1500 mg/天的患者，这种增加更为明显。此外，在年龄<50 岁的人群中，观察到 ω-3 补充剂对该脑因子的作用增加更为显著。
结论
本综述和荟萃回归分析的综合结果表明，ω-3 补充剂可在统计学上显著增加 BDNF 水平。
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