Hjazi Ahmed
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Phytother Res. 2023 Sep;37(9):3859-3866. doi: 10.1002/ptr.7922. Epub 2023 Jun 21.
The electiveness of Capsicum annuum supplementation in controlling dyslipidemia in adults has been unclear. Therefore, this meta-analysis focuses on the relationship between C. annuum supplementation and lipid profile in adults with metabolic syndrome (MetS) and related disorders. PubMed, Scopus, ISI Web of Science, and the Cochrane Library were searched up to March 2021. Only randomized controlled trials (RCTs) studying the administration of C. annuum compared to control on lipid markers in adults with MetS and related disorders were examined. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). The results of four eligible RCTs showed that C. annuum supplementation could significantly reduce total cholesterol (TC) (WMD: -4.98 mg/dL, 95% CI: -7.08 to -2.88, p ≤ 0.001) levels, but did not regulate triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations. In summary, the present findings suggest the beneficial effects of C. annuum supplementation on the reduction of plasma levels of TC. However, to draw a firm link between C. annuum supplementation and lipid profile, more trials with adequate sample sizes, specifically in subjects with dyslipidemia are warranted.
辣椒补充剂在控制成人血脂异常方面的选择性尚不明确。因此，本荟萃分析聚焦于辣椒补充剂与患有代谢综合征（MetS）及相关疾病的成年人血脂水平之间的关系。检索了截至2021年3月的PubMed、Scopus、ISI科学网和考科蓝图书馆。仅纳入了研究辣椒补充剂给药与对照组相比对患有MetS及相关疾病的成年人血脂指标影响的随机对照试验（RCT）。汇总效应量以加权平均差（WMD）和95%置信区间（CI）报告。四项符合条件的RCT结果显示，补充辣椒可显著降低总胆固醇（TC）水平（WMD：-4.98mg/dL，95%CI：-7.08至-2.88，p≤0.001），但对甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇浓度无调节作用。总之，目前的研究结果表明辣椒补充剂对降低血浆TC水平具有有益作用。然而，为了明确辣椒补充剂与血脂水平之间的紧密联系，有必要开展更多样本量充足的试验，特别是针对血脂异常患者的试验。
