HIPK2的甜蜜一面。

The Sweet Side of HIPK2.

作者信息

Garufi Alessia, D'Orazi Valerio, Pistritto Giuseppa, Cirone Mara, D'Orazi Gabriella

机构信息

Unit of Cellular Networks, Department of Research and Advanced Technologies, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

Department of Surgery, Sapienza University, 00185 Rome, Italy.

出版信息

Cancers (Basel). 2023 May 9;15(10):2678. doi: 10.3390/cancers15102678.

DOI:10.3390/cancers15102678

PMID:37345014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10216817/

Abstract

HIPK2 is an evolutionary conserved protein kinase which modulates many molecular pathways involved in cellular functions such as apoptosis, DNA damage response, protein stability, and protein transcription. HIPK2 plays a key role in the cancer cell response to cytotoxic drugs as its deregulation impairs drug-induced cancer cell death. HIPK2 has also been involved in regulating fibrosis, angiogenesis, and neurological diseases. Recently, hyperglycemia was found to positively and/or negatively regulate HIPK2 activity, affecting not only cancer cell response to chemotherapy but also the progression of some diabetes complications. The present review will discuss how HIPK2 may be influenced by the high glucose (HG) metabolic condition and the consequences of such regulation in medical conditions.

摘要

HIPK2是一种进化保守的蛋白激酶，它调节许多参与细胞功能的分子途径，如细胞凋亡、DNA损伤反应、蛋白质稳定性和蛋白质转录。HIPK2在癌细胞对细胞毒性药物的反应中起关键作用，因为其失调会损害药物诱导的癌细胞死亡。HIPK2还参与调节纤维化、血管生成和神经疾病。最近，发现高血糖对HIPK2活性有正向和/或负向调节作用，不仅影响癌细胞对化疗的反应，还影响某些糖尿病并发症的进展。本综述将讨论高葡萄糖（HG）代谢状况如何影响HIPK2，以及这种调节在医学状况中的后果。