Ijaduola G T, Ademiluyi S A, Olarenwaju D A
J Laryngol Otol. 1986 Jul;100(7):823-30. doi: 10.1017/s0022215100100131.
A study of skeletal lesions in the head and neck region of 20 adult patients with von Recklinghausen's disease, seen in the Surgical Out Patient clinic of Lagos University Teaching Hospital from 1979 to 1985, has been carried out. Among the 20 patients, 13 (65 per cent) had symptoms related to the head and neck while 7 (37 per cent) did not; however, on radiological screening, all of them were observed to have skeletal lesions. The commonest feature was enlarged intervertebral nerve root exit foramina from mesodermal dysplasia, which occurred in 16 (80 per cent) of our patients. Other major findings were erosion of the mandible, 8 (40 per cent); erosion of the wings of the sphenoid, 4 (20 per cent); poor mastoid bone pneumatisation, 3 (15 per cent); erosion of the parietal bone, 3 (15 per cent) and heterotopic bone formation, 1 (5 per cent). Congenital calvarial defects were not detected. In view of the fact that all our patients showed radiologically detectable skeletal lesions of the head and neck, despite absence of symptoms in 35 per cent, it is advisable that all patients with von Recklinghausen's disease should routinely have radiological screening of this region, to detect early lesions.
对1979年至1985年在拉各斯大学教学医院外科门诊就诊的20例成年冯·雷克林霍增氏病患者头颈部骨骼病变进行了一项研究。在这20例患者中，13例（65%）有与头颈部相关的症状，7例（35%）没有；然而，经放射学筛查，发现他们所有人都有骨骼病变。最常见的特征是中胚层发育异常导致的椎间神经根出口孔扩大，在我们的16例（80%）患者中出现。其他主要发现包括下颌骨侵蚀8例（40%）；蝶骨翼侵蚀4例（20%）；乳突骨质气化不良3例（15%）；顶骨侵蚀3例（15%）和异位骨形成1例（5%）。未检测到先天性颅骨缺损。鉴于我们所有患者尽管35%没有症状，但经放射学检查均显示头颈部有可检测到的骨骼病变，建议所有冯·雷克林霍增氏病患者应常规对该区域进行放射学筛查，以早期发现病变。
