ShanXi Key Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Center Hospital, Taiyuan, China.
State Key Breeding Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Center Hospital, Taiyuan, China.
Front Immunol. 2023 Jun 6;14:1191645. doi: 10.3389/fimmu.2023.1191645. eCollection 2023.
Psoriasis is a chronic inflammatory skin disease. The histopathological features of psoriasis include excessive proliferation of keratinocytes and infiltration of immune cells. The S100 proteins are a group of EF-hand Ca-binding proteins, including S100A2, -A7, -A8/A9, -A12, -A15, which expression levels are markedly upregulated in psoriatic skin. These proteins exert numerous functions such as serving as intracellular Ca sensors, transduction of Ca signaling, response to extracellular stimuli, energy metabolism, and regulating cell proliferation and apoptosis. Evidence shows a crucial role of S100 proteins in the development and progress of inflammatory diseases, including psoriasis. S100 proteins can possibly be used as potential therapeutic target and diagnostic biomarkers. This review focuses on the pathogenic role of S100 proteins in psoriasis.
银屑病是一种慢性炎症性皮肤病。银屑病的组织病理学特征包括角质形成细胞过度增殖和免疫细胞浸润。S100 蛋白是一组 EF 手 Ca 结合蛋白，包括 S100A2、-A7、-A8/A9、-A12、-A15，在银屑病皮肤中表达水平显著上调。这些蛋白质具有多种功能，如作为细胞内 Ca 传感器、Ca 信号转导、对外界刺激的反应、能量代谢以及调节细胞增殖和凋亡。有证据表明 S100 蛋白在包括银屑病在内的炎症性疾病的发生和发展中起着关键作用。S100 蛋白可能可以作为潜在的治疗靶点和诊断生物标志物。本综述重点介绍了 S100 蛋白在银屑病中的致病作用。
