Chuah Cher Shiong, Fischer Lena, Ho Gwo-Tzer
Edinburgh IBD Science Unit, Centre for Inflammation Research, University of Edinburgh.
Fac Rev. 2023 Jun 14;12:14. doi: 10.12703/r/12-14. eCollection 2023.
This review examines the role of circulating cell-free DNA (cfDNA) as potential drivers of inflammation and their potential application as mechanistic biomarkers in Inflammatory Bowel Diseases (IBD). These DNA fragments contain significant information about their origins, the underlying host pathology leading to their release, and possess properties that can fuel the inflammatory process. Recent advances in sequencing and analytical approaches have made the translation of cfDNA into clinical practice a promising prospect. We focus on the functional relevance of cfDNA in the inflammatory process and discuss its potential for future assessments of IBD activity and identification of therapeutic options.
本综述探讨了循环游离DNA（cfDNA）作为炎症潜在驱动因素的作用及其作为炎症性肠病（IBD）机制生物标志物的潜在应用。这些DNA片段包含有关其来源、导致其释放的潜在宿主病理的重要信息，并具有可加剧炎症过程的特性。测序和分析方法的最新进展使cfDNA转化为临床实践成为一个有前景的前景。我们关注cfDNA在炎症过程中的功能相关性，并讨论其在未来评估IBD活动和确定治疗方案方面的潜力。
