无细胞转录组的细胞起源类型。
Cell types of origin of the cell-free transcriptome.
机构信息
Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
ChEM-H, Stanford University, Stanford, CA, USA.
出版信息
Nat Biotechnol. 2022 Jun;40(6):855-861. doi: 10.1038/s41587-021-01188-9. Epub 2022 Feb 7.
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.
从液体活检中提取的无细胞 RNA 可用于分析以确定疾病的起源组织。我们将这一概念扩展到使用 Tabula Sapiens 转录组细胞图谱以及个体组织转录组细胞图谱，并结合 Human Protein Atlas RNA 共识数据集来识别起源细胞类型。我们定义了细胞类型特征分数，这允许推断出对各种疾病的无细胞 RNA 有贡献的细胞类型。
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