Prenatt Zarian, Liaquat Hammad, Shupp Brittney, Stoll Lisa, Schneider Yecheskel
Department of Internal Medicine, St. Luke's University Health Network, Bethlehem, PA.
Department of Gastroenterology, St. Luke's University Health Network, Bethlehem, PA.
ACG Case Rep J. 2023 Jun 19;10(6):e01091. doi: 10.14309/crj.0000000000001091. eCollection 2023 Jun.
Esophageal neuroendocrine carcinoma is very rare and highly aggressive. An 85-year-old man with a history of esophageal squamous cell carcinoma in remission presented 4 years after definitive chemoradiation with new-onset dysphagia. Endoscopy with biopsy revealed high-grade malignancy consistent with neuroendocrine carcinoma. Treatment options were limited to chemotherapy because of his metastatic disease, and he unfortunately died 14 months after diagnosis. The occurrence of esophageal neuroendocrine carcinoma in a site of prior squamous cell carcinoma is very uncommon, and this likely represents a case of radiation-induced malignancy. Therefore, when undergoing radiotherapy, patients and providers should discuss the possibility of this life-threatening complication.
食管神经内分泌癌非常罕见且侵袭性很强。一名85岁男性，既往有食管鳞状细胞癌病史，已缓解，在确定性放化疗4年后出现新发吞咽困难。内镜检查及活检显示为高级别恶性肿瘤，符合神经内分泌癌。由于他已发生转移，治疗选择仅限于化疗，不幸的是，他在诊断后14个月去世。食管神经内分泌癌发生在既往鳞状细胞癌部位非常罕见，这可能是一例放射诱导的恶性肿瘤。因此，接受放疗时，患者和医护人员应讨论这种危及生命并发症的可能性。
