Singh Gunjesh Kumar, Yadav Vikas, Singh Pragya, Bhowmik K T
Department of Radiotherapy, VMMC and Safdarjung Hospital, New Delhi 110029, India.
Department of Pathology, VMMC and Safdarjung Hospital, New Delhi 110029, India.
World J Oncol. 2016 Dec;7(5-6):119-123. doi: 10.14740/wjon991w. Epub 2016 Dec 23.
Radiotherapy is one of the modalities of treatment of malignancies. Radiation-induced malignancies (RIMs) are late complications of radiotherapy, seen among the survivors of both adult and pediatric cancers. Mutagenesis of normal tissues is the likely basis for RIMs. Till date, RIM cannot be differentiated from primary cancers. We present a series of five patients who were treated at our institute between 2002 and 2016 and were subsequently diagnosed with RIM. Out of five patients, there were two cases of sarcomas, two of carcinomas and one neuroendocrine carcinoma of tongue (rare entity). Separate treatment guidelines are not available for RIM, so the treatment given was same as primary malignancies.
放射治疗是恶性肿瘤的治疗方式之一。辐射诱发的恶性肿瘤（RIMs）是放射治疗的晚期并发症，在成人和儿童癌症幸存者中均有发现。正常组织的诱变可能是RIMs的基础。迄今为止，RIM无法与原发性癌症区分开来。我们报告了2002年至2016年间在我院接受治疗并随后被诊断为RIM的5例患者。5例患者中，有2例肉瘤、2例癌和1例舌部神经内分泌癌（罕见类型）。目前尚无针对RIM的单独治疗指南，因此给予的治疗与原发性恶性肿瘤相同。
