从日本患者中分离的须癣毛癣菌的内部转录间隔区分型。
Internal Transcribed Spacer Region Typing of Trichophyton interdigitale Isolated from Japanese Patients.
机构信息
Teikyo University Institute of Medical Mycology (TIMM), 359 Otsuka, Hachioji, Tokyo, 192-0395, Japan.
Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
出版信息
Mycopathologia. 2023 Aug;188(4):395-399. doi: 10.1007/s11046-023-00763-9. Epub 2023 Jun 22.
Trichophyton interdigitale, an anthropophilic species, is one of the main causative agents of tinea unguium and tinea pedis. T. interdigitale and the zoophilic species T. mentagrophytes are morphologically and physiologically very similar. Isolates of the T. interdigitale/T. mentagrophytes complex from around the world have been classified into more than 10 internal transcribed spacer (ITS) genotypes. In this study, we isolated T. interdigitale from Japanese patients and investigated which ITS type was more common. The ITS regions of 29 clinical isolates of T. interdigitale and one clinical isolate of T. mentagrophytes were sequenced. The phylogenetic analysis of the ITS region sequences revealed that the 29 isolates of T. interdigitale belong to ITS type II of T. interdigitale. The one clinical isolate of T. mentagrophytes was in the same cluster with ITS type II* of T. mentagrophytes. One terbinafine-resistant strain of T. interdigitale also belonged to ITS type II of T. interdigitale.
红色毛癣菌，一种亲人性物种，是甲癣和足癣的主要致病因子之一。红色毛癣菌和嗜动物性物种须癣毛癣菌在形态和生理上非常相似。来自世界各地的红色毛癣菌/须癣毛癣菌复合体的分离株已被分类为超过 10 种内部转录间隔区（ITS）基因型。在这项研究中，我们从日本患者中分离出红色毛癣菌，并研究了哪种 ITS 型更为常见。对 29 株红色毛癣菌临床分离株和 1 株须癣毛癣菌临床分离株的 ITS 区进行了测序。ITS 区序列的系统发育分析显示，29 株红色毛癣菌分离株属于红色毛癣菌 ITS 型 II。须癣毛癣菌的 1 株临床分离株与须癣毛癣菌 ITS 型 II*处于同一聚类中。一株特比萘芬耐药的红色毛癣菌分离株也属于红色毛癣菌 ITS 型 II。
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