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在屎肠球菌中,仅青霉素结合蛋白5就足以支持次最大生长速率,但不能支持最大生长速率。

In Streptococcus faecium penicillin-binding protein 5 alone is sufficient for growth at sub-maximal but not at maximal rate.

作者信息

Canepari P, Lleò M M, Cornaglia G, Fontana R, Satta G

出版信息

J Gen Microbiol. 1986 Mar;132(3):625-31. doi: 10.1099/00221287-132-3-625.

DOI:10.1099/00221287-132-3-625
PMID:3734749
Abstract

In Streptococcus faecium inhibition by both benzylpenicillin and cefotaxime of cells growing at maximal and at reduced rates was associated with saturation of different penicillin-binding proteins. Cells growing at reduced rates were not inhibited by benzylpenicillin concentrations that saturated all penicillin-binding proteins except penicillin-binding protein 5, but did stop growing when this protein was saturated.

摘要

在粪肠球菌中,苄青霉素和头孢噻肟对以最大速率和降低速率生长的细胞的抑制作用与不同青霉素结合蛋白的饱和有关。以降低速率生长的细胞不会被使除青霉素结合蛋白5之外的所有青霉素结合蛋白饱和的苄青霉素浓度所抑制,但当该蛋白饱和时细胞确实会停止生长。

相似文献

1
In Streptococcus faecium penicillin-binding protein 5 alone is sufficient for growth at sub-maximal but not at maximal rate.在屎肠球菌中,仅青霉素结合蛋白5就足以支持次最大生长速率,但不能支持最大生长速率。
J Gen Microbiol. 1986 Mar;132(3):625-31. doi: 10.1099/00221287-132-3-625.
2
One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin.一两种低亲和力青霉素结合蛋白可能是屎肠球菌对苄青霉素敏感性差异的原因。
J Gen Microbiol. 1985 Aug;131(8):1933-40. doi: 10.1099/00221287-131-8-1933.
3
Bacteriostatic and bactericidal activities of beta-lactams against Streptococcus (Enterococcus) faecium are associated with saturation of different penicillin-binding proteins.β-内酰胺类药物对粪肠球菌的抑菌和杀菌活性与不同青霉素结合蛋白的饱和有关。
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4
Inhibition of cell wall synthesis and acylation of the penicillin binding proteins during prolonged exposure of growing Streptococcus pneumoniae to benzylpenicillin.在生长的肺炎链球菌长时间暴露于苄青霉素期间,青霉素结合蛋白的细胞壁合成和酰化受到抑制。
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The VanY(D) DD-carboxypeptidase of Enterococcus faecium BM4339 is a penicillin-binding protein.屎肠球菌BM4339的VanY(D) D-羧肽酶是一种青霉素结合蛋白。
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Shifting of the penicillin binding proteins that are the target for inhibition by beta-lactams as a likely mechanism of resistance to antibiotics during therapy.青霉素结合蛋白的改变作为治疗期间对抗生素耐药的一种可能机制,而青霉素结合蛋白是β-内酰胺类药物的抑制靶点。
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About the affinity of cefotaxime and its anti isomer for the penicillin-binding proteins.关于头孢噻肟及其反式异构体对青霉素结合蛋白的亲和力。
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Penicillin-binding proteins and the intrinsic resistance to beta-lactams in gram-positive cocci.青霉素结合蛋白与革兰氏阳性球菌对β-内酰胺类抗生素的固有耐药性
J Antimicrob Chemother. 1985 Oct;16(4):412-6. doi: 10.1093/jac/16.4.412.

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