葡萄膜炎中视网膜神经纤维层（RNFL）厚度作为生物标志物的研究
The Thickness of the Retinal Nerve Fiber Layer (RNFL) as a Biomarker in Uveitis.
机构信息
Department of Ophthalmology, Torrevieja University Hospital, Torrevieja, Alicante, Spain.
Department of Ophthalmology, FISABIO Oftalmología Médica, Valencia, Spain.
出版信息
Ocul Immunol Inflamm. 2024 Sep;32(7):1243-1249. doi: 10.1080/09273948.2023.2220787. Epub 2023 Jun 22.
AIMS
To study the changes of the retinal nerve fiber layer (RNFL) thickness during and following uveitis flares.
METHODS
This was a retrospective study of patients with uveitis diagnosed in the ophthalmology service of Torrevieja hospital. We analyzed RNFL thickness during and after the acute episode.
RESULTS
We included 29 patients. Most patients (55.2%) had anterior uveitis; followed by posterior, intermediate and panuveitis. Mean RNFL thickness was significantly higher during the flare (132.17±35.54μm vs 107.66±17.10μm). RNFL thickness had no difference between groups with or without macular edema.
CONCLUSIONS
The RNFL thickens during flares in most patients with uveitis. It can be measured by optical coherence tomography in a non-invasive way, representing an objective marker of inflammation. This can favor earlier detection of flares, resolution, and recurrence of uveitis. More studies are needed to determine the evolution of RNFL over time and in different types of uveitis.
目的
研究葡萄膜炎发作期间和之后视网膜神经纤维层（RNFL）厚度的变化。
方法
这是一项在托雷维耶哈医院眼科就诊的葡萄膜炎患者的回顾性研究。我们分析了急性发作期间和之后的 RNFL 厚度。
结果
共纳入 29 名患者。大多数患者（55.2%）患有前葡萄膜炎；其次是后葡萄膜炎、中间葡萄膜炎和全葡萄膜炎。在发作期间，平均 RNFL 厚度明显更高（132.17±35.54μm 比 107.66±17.10μm）。有或没有黄斑水肿的患者之间的 RNFL 厚度没有差异。
结论
大多数葡萄膜炎患者在发作期间 RNFL 会增厚。它可以通过光学相干断层扫描以非侵入性的方式测量，代表炎症的客观标志物。这有助于更早发现发作、炎症的消退和复发。需要更多的研究来确定 RNFL 在不同类型的葡萄膜炎中的随时间的演变。
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