Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Cytokine. 2023 Sep;169:156265. doi: 10.1016/j.cyto.2023.156265. Epub 2023 Jun 20.
Interleukin 17 (IL-17) is an inflammatory cytokine with multiple roles in immune protection, immunopathology, and inflammation-related tumors. Lung cancer is inflammation-related cancer, and a large number of studies have shown that IL-17 contributes to the metastasis and progression of lung cancer. However, some studies have shown that IL17 inhibits the occurrence of lung cancer. At present, there is still some controversy about the role of IL17 in the occurrence and development of lung cancer. This review introduces the basic characteristics of IL-17 and focuses on its role in lung cancer, in order to provide a certain theoretical basis for the prevention, diagnosis, and treatment of lung cancer.
白细胞介素 17（IL-17）是一种具有多种免疫保护、免疫病理和炎症相关肿瘤作用的炎症细胞因子。肺癌是炎症相关的癌症，大量研究表明 IL-17 有助于肺癌的转移和进展。然而，一些研究表明 IL17 抑制了肺癌的发生。目前，关于 IL17 在肺癌发生发展中的作用仍存在一些争议。本综述介绍了 IL-17 的基本特征，并重点介绍了其在肺癌中的作用，以期为肺癌的预防、诊断和治疗提供一定的理论依据。
