人类眼外肌纤维的运动神经支配及乙酰胆碱受体分布

Motor innervation and acetylcholine receptor distribution of human extraocular muscle fibres.

作者信息

Oda K

出版信息

J Neurol Sci. 1986 Jul;74(2-3):125-33. doi: 10.1016/0022-510x(86)90099-7.

Abstract

Motor innervation and acetylcholine receptor distribution of human extraocular muscle (EOM) fibres were investigated by using combined silver and acetylcholinesterase (AChE) staining method and [125I]alpha-bungarotoxin autoradiography. Three types of motor endplates were distinguished; (A) a large compact ending on a large-diameter fibre, (B) several endings regularly spaced on an intermediate-diameter fibre, each of which consisted of small stained particles and (C) numerous small endings scattered as a chain of beads on a small-diameter fibre. Type A fibre was singly innervated, while type B and C had multiterminal (possibly polyneuronal) innervation. These results indicate that the organization of human EOM endplates is quite different from that of limb muscle endplates and may provide some implications to understand the pathophysiology of the neuromuscular diseases, for example, myasthenia gravis.

摘要

采用银染和乙酰胆碱酯酶（AChE）染色相结合的方法以及[125I]α-银环蛇毒素放射自显影技术，对人眼外肌（EOM）纤维的运动神经支配和乙酰胆碱受体分布进行了研究。区分出了三种类型的运动终板：（A）在大直径纤维上的大而紧密的终末；（B）在中等直径纤维上规则间隔排列的多个终末，每个终末由小的染色颗粒组成；（C）在小直径纤维上像一串珠子一样分散的许多小终末。A型纤维由单一神经支配，而B型和C型具有多终末（可能是多神经元）神经支配。这些结果表明，人眼外肌终板的组织结构与肢体肌肉终板有很大不同，可能为理解神经肌肉疾病（如重症肌无力）的病理生理学提供一些启示。