The University of Sydney, School of Psychology, Sydney, NSW, Australia; The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia; The University of Sydney, Faculty of Medicine and Health Translational Research Collective, Sydney, NSW, Australia.
Neuropsychologia. 2023 Sep 9;188:108628. doi: 10.1016/j.neuropsychologia.2023.108628. Epub 2023 Jun 20.
The hemispheric contributions toward interoception, the perception of internal bodily cues, and emotion recognition remains unclear. Semantic dementia cases with either left-dominant (i.e., left-SD) or right-dominant (i.e., right-SD) anterior temporal lobe atrophy experience emotion recognition difficulties, however, little is known about interoception in these syndromes. Here, we hypothesised that right-SD would show worse interoception and emotion recognition due to right-dominant atrophy.
Thirty-five participants (8 left-SD; 6 right-SD; 21 controls) completed a monitoring task. Participants pressed a button when they: (1) felt their heartbeat, without pulse measurement (Interoception); or (2) heard a recorded heartbeat (Exteroception-control). Simultaneous ECG was recorded. Accuracy was calculated by comparing the event frequency (i.e., heartbeat or sound) to response frequency. Emotion recognition was assessed via the Facial Affect Selection Task. Voxel-based morphometry analyses identified neural correlates of interoception and emotion recognition.
Right-SD showed worse interoception than controls and left-SD (both p's < 0.001). Both patient groups showed worse emotion recognition than controls (right-SD: p < .001; left-SD: p = .018), and right-SD showed worse emotion recognition than left-SD (p = .003). Regression analyses revealed that worse emotion recognition was predicted by right-SD (p = .002), left-SD (p = .005), and impaired interoception (p = .004). Interoception and emotion were associated with the integrity of right-lateralised structures including the insula, temporal pole, thalamus, superior temporal gyrus, and hippocampus.
Our study provides the first evidence for impaired interoception in right-SD, suggesting that impaired emotion recognition in this syndrome is driven by inaccurate internal monitoring. Further we identified a common neurobiological basis for interoception and emotion in the right hemisphere.
半球对内感受（对内部身体线索的感知）和情绪识别的贡献仍不清楚。左侧优势（即左侧 SD）或右侧优势（即右侧 SD）前颞叶萎缩的语义性痴呆病例经历情绪识别困难，但对于这些综合征的内感受知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知知，
