行为变异型额颞叶痴呆中内感受的时空脑动力学改变。
Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia.
作者信息
Hazelton Jessica L, Della Bella Gabriel, Barttfeld Pablo, Dottori Martin, Gonzalez-Gomez Raul, Migeot Joaquín, Moguilner Sebastian, Legaz Agustina, Hernandez Hernan, Prado Pavel, Cuadros Jhosmary, Maito Marcelo, Fraile-Vazquez Matias, González Gadea María Luz, Çatal Yasir, Miller Bruce, Piguet Olivier, Northoff Georg, Ibáñez Agustin
机构信息
Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile; Cognitive Neuroscience Centre (CNC), Universidad de San Andres, Buenos Aires, Argentina; The University of Sydney, Brain and Mind Centre, School of Psychology, Sydney, Australia.
Cognitive Science Group, Instituto de Investigaciones Psicológicas (IIPsi, CONICET-UNC), Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina; Facultad de Matemática Astronomía y Física (FaMAF), Universidad Nacional de Córdoba, Córdoba, Argentina.
出版信息
EBioMedicine. 2025 Mar;113:105614. doi: 10.1016/j.ebiom.2025.105614. Epub 2025 Feb 22.
BACKGROUND
Dysfunctional allostatic-interoception, altered processing of bodily signals in response to environmental demands, occurs in behavioural-variant frontotemporal dementia (bvFTD) patients. Previous research has not investigated the dynamic nature of interoception using methods like intrinsic neural timescales. We hypothesised that longer intrinsic neural timescales of interoception would occur in bvFTD patients, evidencing dysfunctional allostatic-interoception.
METHODS
One-hundred and twelve participants (31 bvFTD patients, 35 Alzheimer's disease patients, AD and 46 healthy controls) completed a well-validated task measuring cardiac-interoception and exteroception. Simultaneous EEG and ECG were recorded. Intrinsic neural timescales were measured via the autocorrelation window (ACW) of broadband EEG signals from each heartbeat and a time-lagged version of itself. Spatiotemporal clustering analyses identified clusters with significant between-group differences in each condition. Voxel-based morphometry was used to target the allostatic-interoceptive network. Neuropsychological tests of cognition and social cognition were assessed.
FINDINGS
In bvFTD patients, longer interoceptive-ACWs than controls were observed in the bilateral fronto-temporal and parietal regions. In AD patients, longer interoceptive-ACWs than controls were observed in central and occipitoparietal brain regions. No differences were observed during exteroception. In bvFTD patients only, longer interoceptive-ACW was linked to worse sociocognitive performance. Structural neural correlates of interoceptive-ACW in bvFTD involved the anterior cingulate, insula, orbitofrontal cortex, hippocampus, and angular gyrus.
INTERPRETATION
Our findings suggest a core allostatic-interoceptive deficit occurs in people with bvFTD. Further, altered interoceptive intrinsic neural timescales may provide a neurobiological mechanism underpinning the complex behaviours observed in bvFTD patients. Our findings support synergistic models of brain disease and can inform clinical practice.
FUNDING
All funding sources are reported in the Acknowledgements.
背景
功能失调的适应性内感受，即身体信号处理因环境需求而改变，在行为变异型额颞叶痴呆（bvFTD）患者中出现。以往研究尚未使用如内在神经时间尺度等方法来探究内感受的动态特性。我们假设bvFTD患者会出现更长的内感受内在神经时间尺度，这表明适应性内感受功能失调。
方法
112名参与者（31名bvFTD患者、35名阿尔茨海默病患者、AD和46名健康对照）完成了一项经过充分验证的测量心脏内感受和外感受的任务。同时记录脑电图（EEG）和心电图（ECG）。通过每个心跳的宽带EEG信号及其时间滞后版本的自相关窗口（ACW）来测量内在神经时间尺度。时空聚类分析确定了每种情况下组间存在显著差异的聚类。基于体素的形态测量法用于定位适应性内感受网络。评估了认知和社会认知的神经心理学测试。
结果
在bvFTD患者中，双侧额颞叶和顶叶区域的内感受ACW比对照组更长。在AD患者中，中央和枕顶叶脑区的内感受ACW比对照组更长。在外感受过程中未观察到差异。仅在bvFTD患者中，更长的内感受ACW与更差的社会认知表现相关。bvFTD中内感受ACW的结构神经关联涉及前扣带回、岛叶、眶额皮质、海马体和角回。
解读
我们的研究结果表明bvFTD患者存在核心适应性内感受缺陷。此外，内感受内在神经时间尺度的改变可能为bvFTD患者所观察到的复杂行为提供一种神经生物学机制。我们的研究结果支持脑部疾病的协同模型，并可为临床实践提供参考。
资金
所有资金来源在致谢中报告。
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