Peking University Shenzhen Hospital, Shenzhen, China.
J Dermatol. 2023 Sep;50(9):1156-1161. doi: 10.1111/1346-8138.16856. Epub 2023 Jun 22.
Psoriasis is an immune-mediated chronic, relapsing, inflammatory, systemic disease induced by a combination of genetics and environment. Currently, there are limited reports on the epidemiological and clinical characteristics of geriatric psoriatic patients in mainland China. This study analyzed the epidemiological characteristics, clinical features, and comorbidity rates of geriatric patients with psoriasis and evaluated the influence of age of onset on disease characteristics. This retrospective study enrolled 1259 geriatric patients with psoriasis in hospitals affiliated with the National Standardized Psoriasis Diagnosis and Treatment Center in China from September 2011 to July 2020 to analyze the epidemiological characteristics, clinical features, and prevalence of comorbidity in geriatric psoriasis. The cases were classified according to the age of onset into two groups to compare differences: early-onset psoriasis (EOP) and late-onset psoriasis (LOP). The mean age of geriatric patients with psoriasis was 67, with a 1.8:1 male-to-female ratio and 10.7% positive family history. The clinical manifestations of plaque psoriasis accounted for a high proportion (82.0%) and 85.1% of patients had moderate to severe disease. Overweight (27.8%), hypertension (18.0%), joint involvement (15.8%), diabetes (13.7%), and coronary heart disease (4.0%) were the first five common comorbidities. The LOP group had significantly more patients (79.9%) than the EOP group (20.1%). Positive family history was significantly associated with the EOP group (21.7%) than the LOP group (7.9%). The scalp (60.2%) was the most affected area, followed by the nails (25.3%), palmoplantar region (25.0%), and genitals (12.7%). This study analyzed the epidemiological and clinical characteristics of geriatric psoriasis in China and found that age of onset had no effect on disease characteristics or other comorbidities, except for toenail involvement, diabetes, and joint damage.
银屑病是一种由遗传和环境因素共同作用引起的免疫介导的慢性、复发性、炎症性、全身性疾病。目前，关于中国大陆老年银屑病患者的流行病学和临床特征的报道有限。本研究分析了老年银屑病患者的流行病学特征、临床特征和合并症发生率，并评估了发病年龄对疾病特征的影响。本回顾性研究纳入了 2011 年 9 月至 2020 年 7 月期间在中国国家银屑病标准化诊疗中心附属医院就诊的 1259 例老年银屑病患者，分析了老年银屑病患者的流行病学特征、临床特征和合并症的患病率。根据发病年龄将病例分为两组进行比较：早发型银屑病（EOP）和晚发型银屑病（LOP）。老年银屑病患者的平均年龄为 67 岁，男女比例为 1.8:1，阳性家族史为 10.7%。斑块状银屑病的临床表现占比高（82.0%），85.1%的患者病情为中重度。超重（27.8%）、高血压（18.0%）、关节受累（15.8%）、糖尿病（13.7%）和冠心病（4.0%）是前五种常见合并症。LOP 组患者（79.9%）明显多于 EOP 组（20.1%）。阳性家族史与 EOP 组（21.7%）显著相关，而与 LOP 组（7.9%）无关。头皮（60.2%）是最常受累的部位，其次是指甲（25.3%）、手掌和足底（25.0%）和生殖器（12.7%）。本研究分析了中国老年银屑病的流行病学和临床特征，发现发病年龄对疾病特征或其他合并症无影响，除了脚趾甲受累、糖尿病和关节损伤。
