Phan C, Sigal M-L, Lhafa M, Barthélémy H, Maccari F, Estève E, Reguiai Z, Perrot J-L, Chaby G, Maillard H, Bégon E, Alexandre M, Toussaint P, Bastien-Jacquin M, Bravard P, Sauque E, de Quatrebarbes J, Pfister P, Beauchet A, Mahé E
Department of Dermatology, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prud'hon, 95107 Argenteuil cedex, France.
Department of Dermatology, hôpital Larrey, CHU de Toulouse, université Paul-Sabatier, 31000 Toulouse, France.
Ann Dermatol Venereol. 2016 Apr;143(4):264-74. doi: 10.1016/j.annder.2015.06.024. Epub 2016 Mar 8.
Several studies have shown a high prevalence of cardiovascular and metabolic comorbidities in psoriasis. Our study aimed to evaluate the association of psoriasis with key comorbidities such as smoking, obesity, hypertension, dyslipidaemia and diabetes comparatively with French national data.
This multicentre noninterventional observational study of adults with psoriasis was conducted in 29 dermatology centres in France. A total of 2210 patients were included. The prevalence of comorbidities in psoriatic patients was compared to data from the French national databanks "ObEpi 2012" (obesity, hypertension, dyslipidaemia and diabetes) and "Baromètre Santé 2010" (smoking).
We reported a higher prevalence of all metabolic comorbidities and high blood pressure in psoriatic patients. Smoking: 32.5% were active smokers; the age of onset and the prevalence of familial psoriasis were significantly lower in the smoking group but the severity of psoriasis was significantly higher. The frequency of smoking was higher than in the general population, particularly among young female patients. Obesity: 24% of patients with psoriasis were obese. Multivariate analysis showed obesity to be significantly associated with other comorbidities, severity of psoriasis and psoriatic arthritis. The incidence of obesity was higher than in general population, occurring chiefly in subjects aged over 45 years.
26% of patients with psoriasis had hypertension. The age of onset of psoriasis and the prevalence of psoriatic arthritis were significantly higher in the hypertension group, although there was less familial psoriasis. The incidence of hypertension was higher than in general population. Dyslipidaemia: 27.5% of patients with psoriasis had dyslipidaemia. The age of onset in the dyslipidaemia group was higher although there was less familial psoriasis. The incidence of dyslipidaemia was higher than in general population. Diabetes: 11.0% of patients with psoriasis had diabetes. The age of onset of psoriasis was significantly higher in the diabetes group although there was less familial psoriasis. The incidence of diabetes was higher than in general population particularly after the age of 35 years.
These results confirmed that psoriasis is associated with significant metabolic comorbidities and hypertension compared to the general population in France, with certain epidemiological differences for each.
多项研究表明，银屑病患者中心血管和代谢合并症的患病率很高。我们的研究旨在将法国银屑病患者与关键合并症（如吸烟、肥胖、高血压、血脂异常和糖尿病）的关联与法国国家数据进行比较评估。
这项针对成年银屑病患者的多中心非干预性观察研究在法国的29个皮肤科中心开展。共纳入2210例患者。将银屑病患者中合并症的患病率与法国国家数据库“ObEpi 2012”（肥胖、高血压、血脂异常和糖尿病）及“Baromètre Santé 2010”（吸烟）中的数据进行比较。
我们报告称银屑病患者中所有代谢合并症和高血压的患病率更高。吸烟：32.5%为现吸烟者；吸烟组中银屑病的发病年龄和家族性银屑病的患病率显著更低，但银屑病的严重程度显著更高。吸烟频率高于一般人群，尤其是年轻女性患者。肥胖：24%的银屑病患者肥胖。多变量分析显示肥胖与其他合并症、银屑病严重程度及银屑病关节炎显著相关。肥胖发病率高于一般人群，主要发生在45岁以上人群。
26%的银屑病患者患有高血压。高血压组中银屑病的发病年龄和银屑病关节炎的患病率显著更高，尽管家族性银屑病较少。高血压发病率高于一般人群。血脂异常：27.5%的银屑病患者患有血脂异常。血脂异常组的发病年龄更高，尽管家族性银屑病较少。血脂异常发病率高于一般人群。糖尿病：11.0%的银屑病患者患有糖尿病。糖尿病组中银屑病的发病年龄显著更高，尽管家族性银屑病较少。糖尿病发病率高于一般人群，尤其是35岁以后。
这些结果证实，与法国一般人群相比，银屑病与显著的代谢合并症和高血压相关，且每种合并症存在一定的流行病学差异。
