Dr EXSol Co., Ltd, Seoul, Republic of Korea.
Department of Basic Science Research Institute, Kyungnam University, Changwon, Republic of Korea.
Food Funct. 2023 Jul 3;14(13):6236-6247. doi: 10.1039/d3fo00589e.
: Previous studies suggest that when combined with exercise, -derived β-glucan (APβG) may enhance muscle health and fitness profiles because of its ability to improve exercise-induced fatigue and preserve muscle mass. : The objective was to examine the combined effects and safety of APβG consumption and regular resistance exercise for 12 weeks on muscle strength, biomarkers, and fitness profiles in adults with relatively low skeletal muscle mass. : We conducted a randomized, double-blinded, placebo-controlled trial in adults aged ≥50 years with <110% of the standard lean mass. Eighty participants randomly received either 1000 mg of APβG per day or a placebo for 12 weeks. All participants underwent resistance training three times per week. At baseline and 12 weeks after treatment, we assessed their knee extension/flexion strength, handgrip strength, body composition, and biomarkers. We also evaluated Euro-QoL-5D (EQ-5D) questionnaire, food intake, and physical activity at baseline and 12 weeks after treatment. : The combination of APβG and regular resistance exercise over 12 weeks resulted in a higher right knee flexion strength by 4.49 Nm (95% CI; -0.12-8.86 Nm; = 0.044) than the placebo according to the intention-to-treat analysis. The combination intervention also led to a higher right knee flexion strength of 5.60 Nm (0.18-11.02 Nm; = 0.043) and left knee flexion strength of 7.25 Nm (0.22-14.28 Nm; = 0.043) than the placebo according to the per-protocol (PP) analysis. In addition, compared to the placebo, the combined intervention enhanced right-hand grip strength by 1.40 kg (0.19-2.61 kg; = 0.024) and left-hand grip strength by 1.33 kg (0.01-2.65 kg; = 0.048) according to PP analysis. The combined intervention also resulted in a more significant reduction in the time required for the 400 m walk test than the placebo. None of the participants experienced adverse events. : APβG, in addition to regular resistance exercise, may enhance skeletal muscle strength and fitness in adults with relatively low skeletal muscle mass.
先前的研究表明，当与运动相结合时，来源于真菌的 β-葡聚糖（APβG）可能会通过改善运动引起的疲劳和保持肌肉质量来增强肌肉健康和体能。本研究旨在探究 APβG 联合常规抗阻运动 12 周对骨骼肌质量较低的成年人肌肉力量、生物标志物和体能的综合影响和安全性。我们对年龄在 50 岁及以上且骨骼肌质量低于标准值 110%的成年人进行了一项随机、双盲、安慰剂对照试验。80 名参与者随机每天接受 1000mg 的 APβG 或安慰剂治疗 12 周。所有参与者每周进行三次抗阻训练。在基线和治疗 12 周后，我们评估了他们的膝关节屈伸力量、手握力、身体成分和生物标志物。我们还在基线和治疗 12 周后评估了欧洲五维健康量表（EQ-5D）问卷、食物摄入和身体活动。结果显示，与安慰剂相比，APβG 联合常规抗阻运动 12 周后，右膝屈肌力量提高了 4.49Nm（95%CI：-0.12-8.86Nm； = 0.044）。根据意向治疗分析，联合干预还导致右膝屈肌力量提高了 5.60Nm（0.18-11.02Nm； = 0.043），左膝屈肌力量提高了 7.25Nm（0.22-14.28Nm； = 0.043），优于安慰剂。此外，与安慰剂相比，联合干预通过 PP 分析，右手握力提高了 1.40kg（0.19-2.61kg； = 0.024），左手握力提高了 1.33kg（0.01-2.65kg； = 0.048）。联合干预还导致 400m 步行测试所需时间的减少比安慰剂更显著。所有参与者均未出现不良反应。总之，APβG 联合常规抗阻运动可能会增强骨骼肌质量较低的成年人的骨骼肌力量和体能。
