Cho Young H, Lee Sang Y, Lee Chang-Hyung, Park Jong-Hwan, So Yong S
Department of Family Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Department of Medical Education, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Am J Clin Nutr. 2021 Jun 1;113(6):1440-1446. doi: 10.1093/ajcn/nqaa447.
Studies suggest that Schisandra chinensis Baillon (Sc) may enhance muscle strength and mass because of its anti-inflammatory and antioxidant properties.
We aimed to examine the effects and safety of consumption of Sc extract (SCe) for 12 wk on muscle strength and mass in older adults with relatively low muscle mass who do low-intensity exercise.
A randomized, double-blind, placebo-controlled trial was performed in adults >50 y of age. Fifty-four participants were randomly assigned into 2 groups and, for 12 wk, received either 1 g SCe/d or a placebo. All participants were required to walk for 30-60 min/d for >3 d/wk during the trial period. At baseline and at 4 and 12 wk after treatment, the participants were examined for knee extension strength using Biodex isokinetic dynamometers, handgrip strengths, and body composition, and blood tests were performed. The Euro-QoL-5D (EQ-5D) questionnaire and the FFQ were administered at baseline and at 12 wk after treatment. Physical activity was assessed using a self-recorded daily exercise log and an accelerometer during the study.
SCe supplementation over 12 wk caused a higher increase in right knee extensor strength by 10.2 Nm (95% CI: 3.7, 16.8 Nm; P = 0.003) and left knee extensor strength by 6.7 Nm (95% CI: 0.3, 13.1 Nm; P = 0.041) than did the placebo. However, no differences were observed in the muscle mass, anti-inflammatory markers, antioxidative markers, and EQ-5D score between the groups. None of the participants experienced adverse events.
SCe supplementation may enhance skeletal muscle strength but not mass in older adults who perform low-intensity exercise. This trial was registered at clinicaltrials.gov as NCT03402308.
研究表明，五味子可能因其抗炎和抗氧化特性而增强肌肉力量和质量。
我们旨在研究连续12周服用五味子提取物（SCe）对肌肉质量相对较低且进行低强度运动的老年人肌肉力量和质量的影响及安全性。
对年龄大于50岁的成年人进行了一项随机、双盲、安慰剂对照试验。54名参与者被随机分为两组，连续12周每天服用1 g SCe或安慰剂。在试验期间，所有参与者被要求每周至少3天、每天步行30 - 60分钟。在基线以及治疗后4周和12周时，使用Biodex等速测力计检查参与者的膝关节伸展力量、握力和身体成分，并进行血液检测。在基线和治疗后12周时进行欧洲五维健康量表（EQ - 5D）问卷调查和食物频率问卷（FFQ）。在研究期间，使用自我记录的每日运动日志和加速度计评估身体活动。
与安慰剂相比，连续12周补充SCe使右膝伸肌力量增加了10.2 Nm（95%置信区间：3.7，16.8 Nm；P = 0.003），左膝伸肌力量增加了6.7 Nm（95%置信区间：0.3，13.1 Nm；P = 0.041）。然而，两组之间在肌肉质量、抗炎标志物、抗氧化标志物和EQ - 5D评分方面未观察到差异。没有参与者经历不良事件。
补充SCe可能会增强进行低强度运动的老年人的骨骼肌力量，但不会增加肌肉质量。该试验已在clinicaltrials.gov上注册，注册号为NCT03402308。
