Rodriguez-Hornedo N, Carstensen J T
J Pharm Sci. 1986 Jun;75(6):552-8. doi: 10.1002/jps.2600750606.
Oxalic acid dihydrate was dissolved in binary solvents (acetone:water and glycerol:water) at various saturation temperatures and then cured at higher temperatures. A temperature programmer was used to both heat and cool the solution in a linear fashion. Desupersaturation was followed as a function of time by measuring the changes in solution concentration, and number-based particle size distributions of the resulting crystals were then determined. A model based on the numerical evaluation of the nucleation and growth rates was developed which describes the amount of oxalic acid dihydrate precipitated with respect to time during nonisothermal crystallization. The model allows for calculation of the nucleation and growth rate constants when used with established values of the nucleation and growth orders.
将二水合草酸溶解于二元溶剂（丙酮：水和甘油：水）中，在不同的饱和温度下进行溶解，然后在较高温度下固化。使用温度程序器以线性方式对溶液进行加热和冷却。通过测量溶液浓度的变化跟踪过饱和度随时间的变化情况，然后确定所得晶体基于数量的粒度分布。开发了一个基于成核速率和生长速率数值评估的模型，该模型描述了在非等温结晶过程中二水合草酸相对于时间沉淀的量。当与成核阶数和生长阶数的既定值一起使用时，该模型可用于计算成核速率常数和生长速率常数。
