评估唾液乳酸脱氢酶水平变化用于检测头颈部鳞状细胞癌：一项系统评价和荟萃分析研究

Evaluation of changes in Salivary Lactate Dehydrogenase Level for detection of Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis Study.

作者信息

Abedi Niloufar, Maleki Laleh, Tarrahi Mohammad Javad, Khalesi Saeedeh

机构信息

Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Oral and Maxillofacial Pathology, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan, Iran.

出版信息

Int J Prev Med. 2023 Apr 26;14:50. doi: 10.4103/ijpvm.ijpvm_452_21. eCollection 2023.

DOI:10.4103/ijpvm.ijpvm_452_21

PMID:37351035

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10284214/

Abstract

BACKGROUND

Research has examined the relationship between salivary lactate dehydrogenase (LDH) levels and head and neck squamous cell carcinoma (HNSCC) screening and prognosis. Due to biochemical changes in cancer cells and increased production of lactate products in the body. The present systematic review aims to evaluate the changes in salivary LDH levels in HNSCC patients.

METHODS

The present study is a systematic review and meta-analysis. The data were collected by searching PubMed, Science Direct, Scopus, Web of Science, and Google Scholar from 2000 to 2021. The heterogeneity of the articles was analyzed using I and TAU.

RESULTS

After searching the databases, of 988 articles, 665 duplicated articles were excluded by adopting the inclusion and exclusion criteria. So, 25 articles were primarily selected to be reviewed and evaluated for quality. Finally, 19 articles were selected and analyzed according to the Newcastle-Ottawa checklist. A total of 642 HNSCC patients were reviewed. The meta-analysis showed salivary LDH levels in the HNSCC group were higher than the control group (mean difference = 0.675, standard error = 0.058) ( < 0.001).

CONCLUSIONS

As the research results showed, a significant correlation was observed between salivary LDH levels and HNSCCs. So, LDH can be employed as a valuable and minimally invasive biomarker in head and neck cancer screening and prevention.

摘要

背景

研究探讨了唾液乳酸脱氢酶（LDH）水平与头颈部鳞状细胞癌（HNSCC）筛查及预后之间的关系。由于癌细胞的生化变化以及体内乳酸产物生成增加。本系统评价旨在评估HNSCC患者唾液LDH水平的变化。

方法

本研究为系统评价和荟萃分析。通过检索2000年至2021年期间的PubMed、Science Direct、Scopus、Web of Science和Google Scholar收集数据。使用I²和TAU分析文章的异质性。

结果

检索数据库后，在988篇文章中，根据纳入和排除标准排除了665篇重复文章。因此，初步筛选出25篇文章进行质量审查和评估。最后，根据纽卡斯尔-渥太华清单选择并分析了19篇文章。共纳入642例HNSCC患者进行分析。荟萃分析显示，HNSCC组的唾液LDH水平高于对照组（平均差异 = 0.675，标准误 = 0.058）（P < 0.001）。