Stomatology Department, Universidade Federal Do Paraná, Brazil.
Saliva and Liquid Biopsy Translational Research Team, School of Biomedical Sciences, IHBI/TRI, QUT, Brisbane, Australia.
Expert Rev Mol Diagn. 2020 Mar;20(3):305-313. doi: 10.1080/14737159.2020.1722102. Epub 2020 Jan 27.
: Saliva has gained attention as an important diagnostic fluid because it contains biomolecules that have the potential to detect early-stage cancer or to monitor the response to treatment in patients. Several saliva-based proteins have been proposed as potential biomarkers for head and neck cancers (HNC).: This review aims to provide an update on saliva-based protein biomarkers for HNC, often studied in observational research and clinical trials.: Despite the increasing number of studies relating to salivary proteins as biomarkers for HNC, there is no consensus regarding which proteins have the best clinical utility. Most studies have analyzed individual proteins and not a protein panel approach. It must be considered that combining different proteins as a panel can increase the accuracy and will have the potential to change the current clinical practice for HNC patients.
唾液作为一种重要的诊断液受到关注，因为它含有具有检测早期癌症或监测患者治疗反应潜力的生物分子。已经提出了几种基于唾液的蛋白质作为头颈部癌症（HNC）的潜在生物标志物。
本综述旨在提供有关 HNC 基于唾液的蛋白质生物标志物的最新信息，这些生物标志物通常在观察性研究和临床试验中进行研究。
尽管越来越多的研究涉及作为 HNC 生物标志物的唾液蛋白，但对于哪种蛋白具有最佳临床效用尚无共识。大多数研究分析了单个蛋白质，而不是蛋白质组学方法。必须考虑到，将不同的蛋白质组合成一个面板可以提高准确性，并有可能改变当前 HNC 患者的临床实践。
