Georgy Mark, Salhiyyah Kareem, Yacoub Magdi H, Chester Adrian H
Magdi Yacoub Institute, Heart Science Centre, Harefield, Middlesex, U.K.
Farah General Hospital, Farah Medical Campus, Mai Ziyadeh Street, Amman, Jordan.
Glob Cardiol Sci Pract. 2023 May 11;2023(2):e202309. doi: 10.21542/gcsp.2023.9.
The 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gene expression, cell metabolism, and tissue remodelling that occur in response to low oxygen concentrations are orchestrated by the transcription factor, hypoxia inducible factor-1 (HIF-1). While the effects mediated by HIF-1 have been widely studied, its role in heart valves has only recently been investigated. These studies have shown that HIF-1 expression is evident in mechanisms that regulate the structure and function of heart valves. These include embryonic development, the regulation of the extracellular matrix, angiogenesis and the initiation of the calcification process. This review provides a background on the role and function of HIF-1 in response to hypoxia and a discussion of the available evidence of its involvement in the regulation of heart valves in health and disease.
2016年阿尔伯特·拉斯克基础医学研究奖以及随后的2019年诺贝尔生理学或医学奖授予了小威廉·凯林、彼得·拉特克利夫爵士和格雷格·塞门扎，以表彰他们在细胞如何感知和适应缺氧条件方面所做的工作。他们的研究表明，低氧浓度引发的基因表达、细胞代谢和组织重塑变化是由转录因子缺氧诱导因子-1（HIF-1）协调的。虽然HIF-1介导的效应已得到广泛研究，但其在心脏瓣膜中的作用直到最近才被研究。这些研究表明，HIF-1表达在调节心脏瓣膜结构和功能的机制中很明显。这些机制包括胚胎发育、细胞外基质的调节、血管生成以及钙化过程的启动。本综述提供了HIF-1在应对缺氧时的作用和功能背景，并讨论了其参与健康和疾病状态下心脏瓣膜调节的现有证据。
