Yoshiyama Azusa, Tsujimura Akira, Hiramatsu Ippei, Morino Junki, Anno Yuta, Kurosawa Makoto, Kure Akimasa, Uesaka Yuka, Nozaki Taiji, Shirai Masato, Kiuchi Hiroshi, Horie Shigeo
Department of Urology, Juntendo University, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan; Department of Urology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.
Department of Urology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.
Urology. 2023 Sep;179:50-57. doi: 10.1016/j.urology.2023.06.008. Epub 2023 Jun 22.
To clarify the circadian rhythm of urination in hospitalized women with nocturia measured by toilet uroflowmetry and its age-related change.
We evaluated 2602 urinations of 58 female patients (age, 68.4 ± 15.2 years) who were hospitalized in our institution for urological disease. We assessed voided volume (VV) as averages of every hour by generalized linear mixed models with an identity link function to adjust for personal bias and age. Maximum flow rate and voiding time were analyzed by the same method after adjustment for age, personal bias, and VV. We also compared these circadian rhythms between women <70 and ≥70 years.
VVs in the nighttime were significantly higher than that from 06:00-07:00 (205.6 ± 11.7 ml). Maximum flow rates in the afternoon were significantly higher than that from 06:00-07:00 (18.8 ± 0.93 ml/sec). Voiding time showed no statistically significant difference between the values at any time of day and that from 06:00-07:00. We also showed that the circadian rhythm of VV becomes less clear in the elderly women (P interaction = .0057). However, no significant difference was found in the maximum flow rate and voiding time regarding the pattern of the circadian rhythm between women <70 and ≥70 years old.
The present study clearly showed a circadian rhythm of VV and maximum flow rate in hospitalized women with nocturia. In addition, the pattern of the circadian rhythm of VV was attenuated in women ≥70 years old.
通过马桶尿流率测定法阐明夜尿症住院女性的排尿昼夜节律及其与年龄相关的变化。
我们评估了因泌尿系统疾病在我院住院的58名女性患者（年龄68.4±15.2岁）的2602次排尿情况。通过具有恒等连接函数的广义线性混合模型，将排尿量（VV）评估为每小时的平均值，以调整个体偏差和年龄因素。在调整年龄、个体偏差和VV后，采用相同方法分析最大尿流率和排尿时间。我们还比较了70岁以下和70岁及以上女性之间的这些昼夜节律。
夜间的VV显著高于06:00 - 07:00的排尿量（205.6±11.7毫升）。下午的最大尿流率显著高于06:00 - 07:00的最大尿流率（18.8±0.93毫升/秒）。排尿时间在一天中的任何时间与06:00 - 07:00的值之间均未显示出统计学上的显著差异。我们还表明，老年女性中VV的昼夜节律变得不那么明显（P交互作用 = 0.0057）。然而，在70岁以下和70岁及以上女性之间，关于昼夜节律模式的最大尿流率和排尿时间未发现显著差异。
本研究清楚地显示了夜尿症住院女性中VV和最大尿流率的昼夜节律。此外，70岁及以上女性中VV的昼夜节律模式有所减弱。
