Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Liver Unit, Queen, Elizabeth Hospital Birmingham, Birmingham, UK.
Clin Med (Lond). 2023 Jul;23(4):403-408. doi: 10.7861/clinmed.2022-0556. Epub 2023 Jun 23.
Hepatitis D virus (HDV), also referred to as hepatitis delta virus, is the smallest virus capable of causing human disease. It is unable to replicate on its own and can only propagate in the presence of hepatitis B virus (HBV). Infection with both HBV and HDV frequently results in more severe disease than HBV alone, with higher instances of cirrhosis, liver failure and hepatocellular carcinoma (HCC). Thus, there is a need for effective treatment for HDV; however, currently approved treatment options are very limited both in terms of their efficacy and availability. This makes the management of HDV a challenge for physicians. In this review, we look at the background, diagnosis and treatment of HDV, informed by our hospital data, to set out the optimal management of HDV; we also explore novel treatment options for this disease.
丁型肝炎病毒（HDV），亦称δ肝炎病毒，是能够导致人类疾病的最小病毒。它不能自行复制，只能在乙型肝炎病毒（HBV）存在的情况下进行繁殖。感染 HBV 和 HDV 通常比单独感染 HBV 导致更严重的疾病，肝硬化、肝功能衰竭和肝细胞癌（HCC）的发生率更高。因此，需要对 HDV 进行有效的治疗；然而，目前批准的治疗方案在疗效和可及性方面都非常有限。这使得 HDV 的管理对医生来说是一个挑战。在这篇综述中，我们根据我们医院的数据，探讨了 HDV 的背景、诊断和治疗，以制定 HDV 的最佳管理方案；我们还探索了这种疾病的新的治疗选择。
