Department of Endocrinology, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, No.149 Chongqing South Road, Shanghai, China.
Sci Rep. 2023 Jun 23;13(1):10192. doi: 10.1038/s41598-023-36755-4.
The results of association between Obstructive Sleep Apnea (OSA) and gout are not consistent. Participants aged 20 years or older in the National Health and Nutrition Examination Survey (NHANES) 2007-2008 and 2015-2018 were included. Weighted univariable and multivariable logistic regressions were used to evaluate the association between OSA symptoms and gout. The subgroup and sensitivity analyses were also performed. Among the 15,947 participants in this study, the mean age was 47.8 years old, 48.87% of whom were male, 4891 had OSA symptoms, and 842 had gout. In multivariable logistic regression analyses, OSA symptoms were positively associated with gout in all models. The odds ratio (OR) was 1.315 and 95% confidence interval (CI) was 1.070-1.616 in fully adjusted model 4. In the subgroup analyses, we found a considerable interaction between OSA symptoms and gender with gout (P for interaction = 0.003). In the sensitivity analyses, the association between OSA symptoms and gout remained stable after adjustment for congestive heart failure and diuretics using. OSA symptoms were associated with an increased likelihood of gout. This association could especially be found in female participants.
阻塞性睡眠呼吸暂停（OSA）与痛风之间的关联结果并不一致。本研究纳入了 2007-2008 年和 2015-2018 年国家健康和营养检查调查（NHANES）中年龄在 20 岁及以上的参与者。采用加权单变量和多变量逻辑回归来评估 OSA 症状与痛风之间的关联。还进行了亚组和敏感性分析。在这项研究的 15947 名参与者中，平均年龄为 47.8 岁，其中 48.87%为男性，4891 人有 OSA 症状，842 人患有痛风。在多变量逻辑回归分析中，在所有模型中，OSA 症状与痛风呈正相关。在完全调整后的模型 4 中，比值比（OR）为 1.315，95%置信区间（CI）为 1.070-1.616。在亚组分析中，我们发现 OSA 症状与性别与痛风之间存在显著交互作用（交互作用 P 值=0.003）。在敏感性分析中，在用充血性心力衰竭和利尿剂调整后，OSA 症状与痛风之间的关联仍然稳定。OSA 症状与痛风的可能性增加相关。这种关联在女性参与者中尤为明显。
