The association between genetic polymorphisms in GCKR and gout: A systematic review and meta-analysis.

BACKGROUND

As far as we know, there are no studies summarizing single nucleotide polymorphism (SNP) in the GCKR gene associated with gout, and the association of SNP in the GCKR gene with gout is controversial.

METHODS

Studies were obtained from PubMed, Embase, Web of Science, and Cochrane Library, last searched on February 20, 2024. We reviewed the reported SNP loci of the GCKR gene associated with gout. A meta-analysis was performed to examine the association of SNPs with gout and to investigate whether this association was consistent across populations.

RESULTS

A total of 11 studies were included. 4 GCKR gene SNP loci associated with gout were identified, namely rs780094, rs1260326, rs6547694, rs780093. Meta-analysis showed that SNPs of the GCKR gene were significantly associated with gout (odds ratio [OR]: 1.27; 95% confidence intervals [CI]: 1.21-1.34). Rs780094 (OR: 1.38; 95%CI:1.31-1.44), rs1260326 (OR: 1.26; 95%CI: 1.13-1.39), and rs780093 (OR: 1.17; 95%CI: 1.06-1.27) were all significantly associated with gout. There were no statistically significant differences in effect sizes for rs780094, rs1260326, and rs780093 across populations.

CONCLUSIONS

We identified 4 SNPs of the GCKR gene associated with gout and demonstrated that all these SNPs are important genetic factors for gout risk.