Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Cancer Res Clin Oncol. 2023 Oct;149(13):12507-12512. doi: 10.1007/s00432-023-04969-8. Epub 2023 Jun 23.
Retroperitoneal squamous cell carcinoma is an extremely rare histological variant of retroperitoneal tumors. The exact etiology and origin of the same is still unknown. To date, only a few case reports have been published in the literature. Due to rarity, standard treatment protocol is not available. The article aims to review the literature and treatment options available for this uncommon entity, based on available data.
We searched the databases like PubMed, PubMed Central, Scopus, and Google Scholar with the keywords "Squamous cell carcinoma" and "retroperitoneal tumors". Peer-reviewed and recent articles were screened.
Seven relevant articles comprising 14 cases were found. Due to the small number of reports, tabulation of treatment details and outcome was done. Like the sarcoma variant, these tumors also present with a large mass in the abdomen and abdominal discomfort. Association with human papillomavirus appears to be the most common factor that gives rise to squamous histology.
Retroperitoneal SCC is an uncommonly diagnosed entity. Although no specific treatment guidelines exist for this uncommon malignancy; surgery followed by adjuvant or definitive radiotherapy with concurrent chemotherapy (in inoperable cases) seems a feasible option. Multicentre trials should be conducted for establishing definitive treatment strategies for this ailment.
腹膜后鳞状细胞癌是腹膜后肿瘤一种极为罕见的组织学亚型。其确切的病因和来源仍不清楚。迄今为止，文献中仅发表了少数几例病例报告。由于其罕见性，目前尚无标准的治疗方案。本文旨在根据现有数据，对这一罕见实体的文献和可用治疗选择进行回顾。
我们使用“鳞状细胞癌”和“腹膜后肿瘤”等关键词在 PubMed、PubMed Central、Scopus 和 Google Scholar 等数据库中进行了检索。筛选了同行评议的近期文章。
共发现 7 篇相关文章，其中包含 14 例病例。由于报告数量较少，我们对治疗细节和结果进行了制表。与肉瘤变体一样，这些肿瘤也在腹部出现大肿块和腹部不适。人乳头瘤病毒的相关性似乎是导致鳞状组织学的最常见因素。
腹膜后 SCC 是一种罕见的诊断实体。虽然对于这种罕见的恶性肿瘤尚无特定的治疗指南，但似乎可以选择手术联合辅助或根治性放疗，并在不可手术的情况下联合化疗。应该进行多中心试验，以确定这种疾病的明确治疗策略。
