Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi-do, Korea.
Department of Ophthalmology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
Ann Med. 2023 Dec;55(1):2228192. doi: 10.1080/07853890.2023.2228192.
We sought to evaluate the expression of matrix metalloproteinase-9 (MMP-9) in dry eyes treated with 0.05% cyclosporin A and 3.0% diquafosol tetrasodium.
One-hundred ninety-five eyes of 195 patients with dry eye were divided into three groups as follows: group 1, cyclosporin group ( = 69); group 2, diquafosol group ( = 59); and group 3, artificial tears eyes ( = 67). All eyes were treated and followed up for three months. Schirmer I Test, corneal staining, tear-film break-up time (TBUT), and tear-film MMP-9 content were measured at three months and compared between groups. The expression of MMP-9 was confirmed using a point-of-care test device (InflammaDry®; RPS Diagnostics, Sarasota, FL, USA) and graded as zero to four points.
At the third month, MMP-9 expression was lower in group 1 as compared with in groups 2 and 3 ( 0.020 and 0.006, respectively). The mean MMP-9 grade according to point-of-care testing was also lower in group 1 than in groups 2 or 3 ( 0.002 and 0.038, respectively). MMP-9 showed a correlation with corneal staining in both groups 1 and 2 (all < 0.001) and with Schirmer I Test and TBUT in group 1 ( = 0.018 and 0.015, respectively).
MMP-9 expression and grade were lower after treatment with cyclosporin than after treatment with diquafosol in the dry eye disease. Anti-inflammatory treatment can decrease ocular MMP-9 levels in dry eye disease.
我们旨在评估基质金属蛋白酶-9（MMP-9）在接受 0.05%环孢素 A 和 3.0%双氯非那酸钠治疗的干眼症中的表达。
195 例干眼症患者的 195 只眼分为三组：环孢素组（n=69）、双氯非那酸钠组（n=59）和人工泪液组（n=67）。所有患者接受治疗并随访 3 个月。在 3 个月时测量 Schirmer I 试验、角膜染色、泪膜破裂时间（TBUT）和泪膜 MMP-9 含量，并比较各组之间的差异。使用即时检测设备（InflammaDry®；RPS 诊断公司，萨拉索塔，佛罗里达州，美国）确认 MMP-9 的表达，并分为 0 至 4 分。
在第三个月，与双氯非那酸钠组和人工泪液组相比，环孢素组的 MMP-9 表达水平较低（分别为 0.020 和 0.006）。即时检测结果显示，环孢素组的 MMP-9 评分也低于双氯非那酸钠组或人工泪液组（分别为 0.002 和 0.038）。在两组中，MMP-9 与角膜染色均呈正相关（均 < 0.001），在组 1 中与 Schirmer I 试验和 TBUT 呈正相关（分别为 = 0.018 和 0.015）。
与双氯非那酸钠相比，环孢素治疗干眼症后 MMP-9 的表达和评分均较低。抗炎治疗可降低干眼症患者眼内 MMP-9 水平。
