嗜酸性肉芽肿罕见的斜坡定位：病例说明
Rare clival localization of an eosinophilic granuloma: illustrative case.
作者信息
Weidemeier Martin E, Fleck Steffen, Hosemann Werner, Vogelgesang Silke, Ehlert Karoline, Lode Holger N, Schroeder Henry W S
机构信息
Departments of1Neurosurgery.
2Otolaryngology, Head & Neck Surgery, and.
出版信息
J Neurosurg Case Lessons. 2023 Jun 19;5(25). doi: 10.3171/CASE22490.
BACKGROUND
Eosinophilic granuloma (EG) belongs to the family of Langerhans cell histiocytosis (LCH) and is considered to be a benign disease typically found in children younger than 15 years of age. Here, the authors describe an EG of unusual localization and clinical presentation.
OBSERVATIONS
The authors report a 9-year-old girl with an EG presenting as an osteolytic lesion of the clivus. After transsphenoidal resection and histological confirmation, adjuvant chemotherapy was initiated. Presenting signs and symptoms were weight loss, episodic grimacing, and moderate ballism-like movements. After a follow-up-period of 32 months, the patient presented with a total resolution of initial symptoms and no further tumor growth.
LESSONS
Although these lesions are rare, one should consider EG as a differential diagnosis when confronted with osteolytic lesions of the clivus.
背景
嗜酸性肉芽肿（EG）属于朗格汉斯细胞组织细胞增多症（LCH）家族，被认为是一种通常在15岁以下儿童中发现的良性疾病。在此，作者描述了一例具有不寻常定位和临床表现的EG。
观察结果
作者报告了一名9岁女孩，其EG表现为斜坡的溶骨性病变。经蝶窦切除并组织学确诊后，开始辅助化疗。呈现的体征和症状为体重减轻、发作性鬼脸和中度舞蹈样动作。经过32个月的随访期，患者最初症状完全消失，且无肿瘤进一步生长。
经验教训
尽管这些病变罕见，但当面对斜坡溶骨性病变时，应将EG作为鉴别诊断之一。
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