Hoover Kevin Bradford, Rosenthal Daniel I, Mankin Henry
Musculoskeletal Radiology, Massachusetts General Hospital, Yawkey 6E 55 Fruit Street, Boston, MA 02114, USA.
Skeletal Radiol. 2007 Feb;36(2):95-104. doi: 10.1007/s00256-006-0193-2. Epub 2006 Oct 7.
Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian's disease, which involves multiple organ systems and, most typically, the skull base; and Letterer-Siwe's disease, the most severe disease manifestation, which typically involves the abdominal viscera. This article reviews our current understanding of Langerhans cell histiocytosis by discussing the history, histology, etiology, and treatment of the disease. It focuses on the radiographic findings and imaging modalities that are the most useful in disease diagnosis and management.
朗格汉斯细胞组织细胞增多症（LCH）是一种复杂的疾病实体，由三种不同的临床综合征组成，这些综合征具有难以区分的组织学特征。这些综合征包括：嗜酸性肉芽肿，主要累及骨骼或肺部；汉-许-克病，累及多个器官系统，最典型的是累及颅底；勒-雪病，是最严重的疾病表现形式，通常累及腹部脏器。本文通过讨论该疾病的历史、组织学、病因和治疗，综述了我们目前对朗格汉斯细胞组织细胞增多症的认识。它重点介绍了在疾病诊断和管理中最有用的影像学表现和成像方式。
