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癌症患儿同胞创伤后应激症状轨迹:诊断后头两年。

Trajectories of Traumatic Stress Symptoms Among Siblings of Children With Cancer: The First Two Years Post-Diagnosis.

机构信息

The Center for Healthcare Delivery Science, Nemours Children's Hospital-Delaware, Wilmington, DE, USA.

Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

J Pediatr Psychol. 2023 Aug 29;48(8):688-699. doi: 10.1093/jpepsy/jsad033.

Abstract

OBJECTIVE

Identify and describe trajectories of cancer-related posttraumatic stress symptoms (PTSS) among siblings of children with cancer within two years of diagnosis.

METHOD

Siblings (aged 8-18; M = 11.2 years) across the United States, and for each, one caregiver, were recruited for a cohort sequential longitudinal study with three data collection points six months apart beginning at 6- or 12-months after cancer diagnosis. Siblings (N = 229; 42% of eligible/approached; 53% identifying as female; 68% identifying as non-Hispanic White) completed the Child Posttraumatic Stress Disorder Symptom Scale. Caregivers completed the Strengths and Difficulties Questionnaire (SDQ). Latent class growth analysis (LCGA) and growth mixture modeling (GMM) identified PTSS patterns across time.

RESULTS

Fit statistics supported models with three to five PTSS trajectories. The three-class LCGA model included a large mild PTSS group (61%), a moderate PTSS group (35%), and a small (4%) stable severe PTSS group. The four-class LCGA and three- and four-class GMM included groups improving from moderate to mild PTSS (7-21%) and worsening to moderate PTSS across time (12-17%). Across models, siblings with mild PTSS had fewer caregiver-reported emotional and behavioral difficulties on the SDQ.

CONCLUSIONS

A large group of siblings of children with cancer demonstrate resiliency, however, substantial subsets experience patterns of PTSS that include levels in the moderate-to-severe range during the first two years post-diagnosis. Future research should examine these patterns in more diverse/representative samples and identify factors associated with increasing and sustained severe PTSS to inform intervention targets and reduce cancer-related burden on families.

摘要

目的

在儿童癌症诊断后两年内,确定并描述癌症相关创伤后应激症状(PTSS)在癌症患儿兄弟姐妹中的轨迹。

方法

在美国招募了兄弟姐妹(年龄 8-18 岁;M=11.2 岁)及其一名照顾者,进行了一项队列序贯纵向研究,从癌症诊断后 6 至 12 个月开始,每六个月收集三次数据。兄弟姐妹(N=229;占合格/接触的 42%;53%为女性;68%为非西班牙裔白人)完成了儿童创伤后应激障碍症状量表。照顾者完成了长处和困难问卷(SDQ)。潜在类别增长分析(LCGA)和增长混合建模(GMM)确定了随时间变化的 PTSD 模式。

结果

拟合统计支持具有三到五个 PTSD 轨迹的模型。三类别 LCGA 模型包括一个大的轻度 PTSD 组(61%)、一个中度 PTSD 组(35%)和一个稳定的严重 PTSD 组(4%)。四类别 LCGA 和三类别和四类别 GMM 包括从中度 PTSD 改善到轻度 PTSD 的组(7-21%)和随时间恶化到中度 PTSD 的组(12-17%)。在所有模型中,轻度 PTSD 的兄弟姐妹在照顾者报告的 SDQ 中情绪和行为困难较少。

结论

很大一部分癌症患儿的兄弟姐妹表现出韧性,但相当一部分人在诊断后两年内经历了 PTSD 模式,包括中度到重度 PTSD 水平。未来的研究应在更多的多样化/代表性样本中检查这些模式,并确定与持续严重 PTSD 相关的因素,以确定干预目标并减轻癌症对家庭的负担。

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