Peng Yundong, Wang JiePing, Liu Xinyao, Zhou Yanqing, Jia Shaohui, Xu Jinrong, Zheng Cheng
School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
Laboratory of Exercise Biochemistry, Institute of Sports Sciences, University of Taipei, Taipei, Taiwan.
Ann Vasc Surg. 2024 Jan;98:365-373. doi: 10.1016/j.avsg.2023.05.045. Epub 2023 Jun 22.
The probiological healing effect of platelet-rich plasma (PRP) during tissue repair has recently gathered much attention. This study aimed to conduct a systematic review and meta-analysis of patients with diabetic foot ulcer (DFU) receiving PRP or conventional treatment to evaluate their efficacy.
PubMed, Excerpta Medica Database (EMBASE), Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases were comprehensively searched by 2 independent reviewers following PRISMA guidelines for the inclusion of randomized controlled trials (RCTs) comparing PRP with conventional treatments for DFUs. The primary measurements of healing rate and healing time, the methodological quality and extracted data were assessed using Review Manager 5.3. Statistical significance was set at P < 0.05.
A total of 10 RCTs involving 550 patients were included in this study, PRP was observed to significantly improve the healing rate (risk ratio [RR] = 1.38, 95% confidence interval [CI] 1.05-1.82, P = 0.02) and shorten the healing time (mean difference [MD] = -23.23, 95% CI -45.97 to -0.49, P = 0.05) of patients with DFU when compared to the conventional treatment.
Compared to conventional treatment, PRP effectively promoted the healing of patients with DFU by evidently improving the healing rate and healing time.
富含血小板血浆（PRP）在组织修复过程中的益生愈合作用最近备受关注。本研究旨在对接受PRP或传统治疗的糖尿病足溃疡（DFU）患者进行系统评价和荟萃分析，以评估其疗效。
由两名独立审阅者按照PRISMA指南全面检索PubMed、医学文摘数据库（EMBASE）、Cochrane图书馆和中国知网（CNKI）数据库，纳入比较PRP与DFU传统治疗方法的随机对照试验（RCT）。使用Review Manager 5.3评估愈合率和愈合时间的主要测量指标、方法学质量及提取的数据。设定统计学显著性为P < 0.05。
本研究共纳入10项涉及550例患者的RCT，结果显示与传统治疗相比，PRP能显著提高DFU患者的愈合率（风险比[RR]=1.38，95%置信区间[CI] 1.05 - 1.82，P = 0.02）并缩短愈合时间（平均差[MD]= - 23.23，95% CI - 45.97至 - 0.49，P = 0.05）。
与传统治疗相比，PRP通过显著提高愈合率和缩短愈合时间，有效促进了DFU患者的愈合。
