肿瘤性炎症浸润并不能预测薄型原发性皮肤黑色素瘤的转移。

Tumoral inflammatory infiltrate does not predict metastases in thin primary cutaneous melanomas.

机构信息

Department of Dermatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil; Universidade Luterana do Brasil, Canoas, RS, Brazil.

Department of Dermatology, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil.

出版信息

An Bras Dermatol. 2023 Nov-Dec;98(6):793-798. doi: 10.1016/j.abd.2022.09.011. Epub 2023 Jun 22.

DOI:10.1016/j.abd.2022.09.011

PMID:37355350

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10589460/

Abstract

BACKGROUND

In cutaneous melanomas in general, tumor inflammatory infiltrate (TII) can protect against distant metastases, but there is no consensus when only thin primary cutaneous melanomas (TPCM) are considered.

OBJECTIVE

To investigate the presence of TII in TPCM and the relationship between TII and the occurrence of metastases.

METHODS

Case-control study including 50 patients with TPCM, 22 metastatic (MC group) and 28 non-metastatic (NMC group). The presence of TII was evaluated and, if present, qualified as mild, moderate or marked.

RESULTS

The mean age was 50.7 years in the MC and 56.2 years in the NMC group (p = 0.234), and the male sex predominated in the MC group (63.6%). The average Breslow thickness was higher in the MC when compared to that observed in the NMC (respectively 0.8 vs. 0.6 mm, p = 0.012). The presence of ulceration occurred in 22.7% of the MC and 17.9% of the NMC (p = 0.732). TII was present in all 50 TPCM, being marked or moderate in 67.9% of the NMC and 54.5% in the MC group (p = 0.503). In the multivariate analysis, the presence of moderate and marked TII had an Odds Ratio (OR) of 0.57 (95% Confidence Interval [CI]: 0.18‒1.8) and adjusted OR of 0.68 (95% CI 0.13‒3.99).

STUDY LIMITATIONS

Small sample size.

CONCLUSIONS

TII was present in all TPCM (with and without metastases), and it was not possible to demonstrate a protective effect of TII against the appearance of metastases.

摘要

背景

一般来说，肿瘤炎症浸润（TII）可以保护皮肤黑色素瘤免受远处转移，但当仅考虑薄型原发性皮肤黑色素瘤（TPCM）时，尚无共识。

目的

研究 TPCM 中 TII 的存在情况以及 TII 与转移发生之间的关系。

方法

包括 50 例 TPCM 患者的病例对照研究，其中 22 例为转移性（MC 组），28 例为非转移性（NMC 组）。评估 TII 的存在情况，如果存在，则将其定性为轻度、中度或重度。

结果

MC 组的平均年龄为 50.7 岁，NMC 组为 56.2 岁（p=0.234），MC 组男性居多（63.6%）。MC 组的平均 Breslow 厚度高于 NMC 组（分别为 0.8 与 0.6mm，p=0.012）。MC 组中溃疡的发生率为 22.7%，NMC 组为 17.9%（p=0.732）。所有 50 例 TPCM 均存在 TII，NMC 组中有 67.9%为中重度，MC 组中有 54.5%（p=0.503）。多变量分析显示，中重度 TII 的存在 OR 为 0.57（95%置信区间 [CI]：0.18-1.8），调整后的 OR 为 0.68（95%CI 0.13-3.99）。