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黑色素瘤显微镜诊断的分析前和分析后指南:巴西病理学会的建议

Pre and post-analytical guidelines for the microscopic diagnosis of melanoma: recommendations from the Brazilian Society of Pathology.

作者信息

Xavier-Júnior José Cândido Caldeira, Coelho Karina Munhoz de Paula Alves, Macedo Mariana Petaccia de, Lellis Rute Facchini, Pinheiro Junior Nathanael de Freitas, Rocha Robledo Fonseca

机构信息

Instituto de Patologia de Araçatuba, Araçatuba, SP, Brazil; Faculty of Medicine, Centro Universitário Católico Unisalesiano, Araçatuba, SP, Brazil; Postgraduate Program in Pathology, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.

CEDAP, Centro de Diagnósticos Anátomo-Patológicos, Joinville, SC, Brazil; Instituto Nacional de Ciência e Tecnologia em Biologia do Câncer Infantil e Oncologia Pediátrica ‒ INCT BioOncoPed, Brazil.

出版信息

An Bras Dermatol. 2025 Jul 3;100(4):501139. doi: 10.1016/j.abd.2025.501139.

DOI:10.1016/j.abd.2025.501139
PMID:40614549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12270780/
Abstract

The guidelines project of the Brazilian Society of Pathology aims to disseminate recommendations for pathologists, surgeons, and clinicians, based on solid data from the literature and through adaptations of international guidelines to the reality of Brazilian physicians. This article is the result of the efforts of a group of pathologists, members of the Dermatopathology Committee of the Brazilian Society of Pathology, focused on melanocytic diseases, who, through topics, established pertinent recommendations for clinicians and surgeons for the accurate diagnosis of melanocytic lesions suspected of melanoma. This article aims to clarify the best way to perform excision in cases of suspected melanocytic lesions, as well as the pre-analytical care related to the material, how to interpret the anatomopathological report, and the situations in which immunohistochemical and molecular studies can be auxiliary tools for diagnosis and/or therapy.

摘要

巴西病理学会的指南项目旨在依据文献中的可靠数据,并通过使国际指南适应巴西医生的实际情况,向病理学家、外科医生和临床医生传播相关建议。本文是巴西病理学会皮肤病理学委员会一群专注于黑素细胞疾病的病理学家努力的成果,他们通过各个主题,为临床医生和外科医生建立了有关准确诊断疑似黑色素瘤的黑素细胞病变的相关建议。本文旨在阐明疑似黑素细胞病变病例中进行切除的最佳方法,以及与标本相关的分析前处理、如何解读解剖病理学报告,以及免疫组织化学和分子研究可作为诊断和/或治疗辅助工具的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/4d3448bd6972/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/4526bbca408b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/50c0d0cf9568/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/6146984d0935/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/f32c4abfd601/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/a02519db8f8c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/843f19aff3e6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/2339215552de/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/4d3448bd6972/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/4526bbca408b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/50c0d0cf9568/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/6146984d0935/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/f32c4abfd601/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/a02519db8f8c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/843f19aff3e6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/2339215552de/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ed/12270780/4d3448bd6972/gr8.jpg

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本文引用的文献

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Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据:全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4.
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Proposal for the applicability of modified Breslow (measured from the basal membrane) as a predictor of survival and sentinel lymph node outcome in patients with cutaneous melanoma.改良 Breslow(从基底膜测量)在预测皮肤黑色素瘤患者生存和前哨淋巴结结果中的适用性的建议。
An Bras Dermatol. 2024 May-Jun;99(3):398-406. doi: 10.1016/j.abd.2023.09.002. Epub 2024 Feb 19.
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Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review.
PRAME 免疫组化在大型黑素细胞和非黑素细胞病变系列中的陷阱:文献复习。
Am J Dermatopathol. 2024 Jan 1;46(1):21-30. doi: 10.1097/DAD.0000000000002584.
4
Sentinel lymph node assessment in melanoma: current state and future directions.黑色素瘤前哨淋巴结评估:现状与未来方向。
Histopathology. 2023 Nov;83(5):669-684. doi: 10.1111/his.15011. Epub 2023 Aug 1.
5
Tumoral inflammatory infiltrate does not predict metastases in thin primary cutaneous melanomas.肿瘤性炎症浸润并不能预测薄型原发性皮肤黑色素瘤的转移。
An Bras Dermatol. 2023 Nov-Dec;98(6):793-798. doi: 10.1016/j.abd.2022.09.011. Epub 2023 Jun 22.
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Epidemiology of cutaneous melanoma in Blumenau, Santa Catarina state, Brazil from 1980 to 2019.巴西圣卡塔琳娜州布卢梅瑙地区 1980 年至 2019 年皮肤黑色素瘤的流行病学研究。
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