Radiologist, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Assistant Professor of Radiology Department, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Med Imaging Radiat Sci. 2023 Sep;54(3):446-450. doi: 10.1016/j.jmir.2023.05.044. Epub 2023 Jun 22.
Breast cancer is the most common malignancy among women, and subtypes are mainly defined based on hormone receptors such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). The relationship between breast cancer subtypes and imaging features in mammography and sonography has been studied but the results are controversial. The purpose of this study was to determine the relationship between the hormonal receptor status of breast tumors and the radiologic feature of the tumors on mammography and sonography.
Eighty patients with breast cancer enrolled in this cross-sectional study. ER, PR, and HER2 determined by immunohistochemistry. Every patient underwent mammography and sonography before the biopsy. We evaluated the relationship between the hormonal receptor status and radiographic features of tumors on breast sonography and mammography.
The majority of the patients (n=75 (93.8%)) were diagnosed with invasive ductal carcinoma (IDC). The mean and standard deviation of the age was 49 ± 9 years. There was no significant relationship between the hormonal receptor status and the sonographic margin and shape (P>0.05). However, PR (P=0.002) and ER (P=0.001) status were significantly correlated with posterior features on sonography. ER-positive patients were more likely to have indistinct or speculated masses on mammography (P=0.017). Irregular or oval masses on mammography were higher in patients with ER (p=0.032).
There was a significant correlation between PR and ER status and posterior features on sonography. Positive ER was associated with indistinct or speculated masses on mammography, as well as irregular or oval masses.
乳腺癌是女性最常见的恶性肿瘤，亚型主要根据激素受体（如雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体 2（HER2））来定义。乳腺癌亚型与乳腺 X 线摄影和超声的影像学特征之间的关系已经得到研究，但结果存在争议。本研究旨在确定乳腺肿瘤的激素受体状态与乳腺 X 线摄影和超声肿瘤的影像学特征之间的关系。
本横断面研究纳入了 80 例乳腺癌患者。采用免疫组织化学法测定 ER、PR 和 HER2。每位患者在活检前均进行乳腺 X 线摄影和超声检查。我们评估了激素受体状态与乳腺超声和乳腺 X 线摄影肿瘤的影像学特征之间的关系。
大多数患者（n=75（93.8%））被诊断为浸润性导管癌（IDC）。年龄的平均值和标准差为 49±9 岁。激素受体状态与超声边缘和形态之间无显著关系（P＞0.05）。然而，PR（P=0.002）和 ER（P=0.001）状态与超声的后特征显著相关。ER 阳性患者在乳腺 X 线上更可能出现边界不清晰或有分叶的肿块（P=0.017）。在 ER 阳性患者中，乳腺 X 线上的不规则或椭圆形肿块更多（p=0.032）。
PR 和 ER 状态与超声的后特征之间存在显著相关性。阳性 ER 与乳腺 X 线上边界不清晰或有分叶的肿块以及不规则或椭圆形肿块相关。
