Department of Clinical Oncology, Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Department of Otolaryngology - Head and Neck Surgery, The Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Clin Oncol (R Coll Radiol). 2023 Sep;35(9):e489-e497. doi: 10.1016/j.clon.2023.06.011. Epub 2023 Jun 16.
A systematic review was carried out to evaluate if adjuvant radiotherapy for acinic cell carcinomas (ACCs) of salivary glands improves survival. Twelve retrospective studies published between 2000 and 2020 that analysed the effect of radiotherapy on salivary gland neoplasms and ACCs of salivary glands and met the inclusion criteria were included in the review. The overall quality of the studies was moderate to low. There was no high-quality evidence for improved survival with radiotherapy for ACCs of the salivary gland. Some evidence suggests that there may be an advantage for patients with high-grade tumours, but these data should be interpreted with caution due to the small number of patients and low-quality evidence. Good quality of evidence is lacking. Recommendation for adjuvant radiotherapy for tumours with poor prognostic factors will require discussion and shared decision-making with the patients.
一项系统评价评估了辅助放疗是否能改善涎腺腺样囊性癌（ACC）患者的生存率。该评价纳入了 2000 年至 2020 年期间发表的 12 项回顾性研究，这些研究分析了放疗对涎腺肿瘤和涎腺 ACC 的影响，并符合纳入标准。研究的整体质量为中低等。没有高质量证据表明放疗能提高 ACC 患者的生存率。有一些证据表明，对于高级别肿瘤的患者可能存在优势，但由于患者数量少和证据质量低，这些数据应谨慎解释。目前缺乏高质量的证据。对于具有不良预后因素的肿瘤，辅助放疗的建议需要与患者进行讨论和共同决策。
