Maggi C A, Santicioli P, Giuliani S, Furio M, Meli A
J Urol. 1986 Sep;136(3):696-700. doi: 10.1016/s0022-5347(17)45030-0.
The functional role of the capsaicin-sensitive innervation of the rat urinary bladder in regulating micturition has been investigated by means of the transvesical cystometrogram which allows study of the effects of drugs on the various phases of the bladder voiding cycle in urethane-anesthetized rats. Capsaicin desensitization (50-125 mg./kg., 4 to 60 days before) significantly increased both the volume and pressure threshold for micturition, indicating functional impairment of the mechanisms which transmit volume information from the bladder to the central nervous system. On the other hand the parameters related to the expulsive phase of the voiding cycle of the rat bladder are unaffected by capsaicin pretreatment. In capsaicin-desensitized rats the bladder weight remained within the limits of controls up to 60 days from the treatment although at this time the volume threshold was still elevated. In capsaicin-desensitized rats an increase of infusion rate above the physiological range produced micturition cycles having a normal volume and pressure threshold. These findings suggest that at high values of volume/pressure threshold micturition could be initiated through capsaicin-resistant sensory mechanism(s); in effect, multiple sensory systems, having different thresholds, relay volume/pressure information from the detrusor to the CNS.
通过经膀胱膀胱内压测量法研究了大鼠膀胱辣椒素敏感神经支配在调节排尿中的功能作用，该方法可用于研究药物对氨基甲酸乙酯麻醉大鼠膀胱排尿周期各阶段的影响。辣椒素脱敏（50 - 125毫克/千克，提前4至60天）显著增加了排尿的容量阈值和压力阈值，表明从膀胱向中枢神经系统传递容量信息的机制存在功能障碍。另一方面，与大鼠膀胱排尿周期排出期相关的参数不受辣椒素预处理的影响。在辣椒素脱敏的大鼠中，直至治疗后60天膀胱重量仍保持在对照组范围内，尽管此时容量阈值仍升高。在辣椒素脱敏的大鼠中，高于生理范围的输注速率增加会产生具有正常容量阈值和压力阈值的排尿周期。这些发现表明，在高容量/压力阈值时，排尿可通过辣椒素抗性感觉机制启动；实际上，多个具有不同阈值的感觉系统将容量/压力信息从逼尿肌传递至中枢神经系统。
