Maggi C A, Santicioli F, Meli A
Department of Pharmacology, A. Menarini, Pharmaceutical Co. Ltd., Firenze, Italy.
Acta Physiol Hung. 1987;69(3-4):425-35.
Functional evidence is presented indicating the presence in the rat urinary bladder of a capsaicin-sensitive innervation which is involved in regulating micturition threshold. Endogenous substance P and/or related tachykinins appear to be present in the capsaicin-sensitive nerve endings of the rat bladder and may play a neurotransmitter role in relaying information concerned with bladder volume from the detrusor muscle to the central nervous system. In addition, neurotransmitter release from the peripheral ending of the capsaicin-sensitive fibers may play an efferent role in certain motor and/vascular responses at bladder muscle level.
有功能证据表明，大鼠膀胱中存在对辣椒素敏感的神经支配，其参与调节排尿阈值。内源性P物质和/或相关速激肽似乎存在于大鼠膀胱对辣椒素敏感的神经末梢中，并且可能在将与膀胱容量相关的信息从逼尿肌传递至中枢神经系统的过程中发挥神经递质作用。此外，辣椒素敏感纤维外周末梢释放的神经递质可能在膀胱肌肉水平的某些运动和/血管反应中发挥传出作用。
