Bratt C G, Granerus G
J Urol. 1986 Sep;136(3):728-32. doi: 10.1016/s0022-5347(17)45037-3.
The absorption of 125I-hippuran from human renal pelvis was studied peroperatively in 18 patients with obstruction at the pelviureteric junction. Three types of experiment were included: absorption during induced diuresis, absorption at a constant intrapelvic pressure of 30 cm. H2O, and excretion of the indicator by the contralateral kidney. Total and separate glomerular filtration rate were measured using 51Cr-EDTA clearance technique and isotope renography. Distal tubular function was evaluated as maximum concentration ability. During induced diuresis the intrapelvic pressure increased to an average maximum value of 31.6 cm. H2O. The excretion of isotope from the contralateral kidney varied from one to 44% of the given dose. A significant correlation (r = 0.87) between the maximum intrapelvic pressure obtained and the amount of isotope excreted from the contralateral kidney was demonstrated. At a constant intrapelvic pressure of 30 cm. H2O the excretion of isotope from the contralateral kidney varied from two to 26% of the dosage given. The low value probably depended on the impaired function of the obstructed kidney. Our results show the existence of a significant reflux from the renal pelvis of small molecules, which was affected by renal function, intrapelvic pressure and volume.
对18例肾盂输尿管连接处梗阻患者在手术中研究了125I-马尿酸从肾盂的吸收情况。包括三种类型的实验：诱导利尿期间的吸收、肾盂内压力恒定为30 cmH₂O时的吸收以及对侧肾脏对指示剂的排泄。使用51Cr-EDTA清除技术和同位素肾图测量总肾小球滤过率和单独的肾小球滤过率。将远端肾小管功能评估为最大浓缩能力。诱导利尿期间肾盂内压力平均升高至最大值31.6 cmH₂O。对侧肾脏同位素的排泄量占给药剂量的1%至44%。结果表明，所获得的最大肾盂内压力与对侧肾脏排出的同位素量之间存在显著相关性（r = 0.87）。在肾盂内压力恒定为30 cmH₂O时，对侧肾脏同位素的排泄量占给药剂量的2%至26%。低值可能取决于梗阻肾脏功能受损。我们的结果表明存在小分子从肾盂的显著反流，这受到肾功能、肾盂内压力和容量的影响。
