Bratt C G, Aurell M, Jonsson O, Nilsson S
Eur Urol. 1986;12(5):334-9. doi: 10.1159/000472650.
The influence on urinary excretion of sodium (NNa . V) of intrapelvic pressure, urinary flow, and mean arterial blood pressure during forced diuresis was evaluated in 12 patients with unilateral hydronephrosis. Total and divided renal functions were measured using 51Cr-EDTA clearance and isotope renography. The amount of sodium, excreted by the obstructed kidney, decreased with higher maximum intrapelvic pressure and increased with higher differences between the mean arterial blood pressure and maximum intrapelvic pressure. The higher the concentrating ability, the lower the amount of sodium excreted by the obstructed kidney. There was a highly significant negative correlation between maximum intrapelvic pressure and urinary flow, but no correlation between mean arterial blood pressure and maximum intrapelvic pressure. Thus, obstructed kidneys with normal concentrating ability have the same excretion of sodium as the nonobstructed contralateral kidney during forced diuresis. Obstructed kidneys with decreased concentrating ability on the other hand excrete comparatively more sodium. This is probably due to a defect in sodium resorption.
对12例单侧肾积水患者在强制利尿期间肾盂内压、尿流和平均动脉血压对尿钠排泄（NNa.V）的影响进行了评估。使用51Cr-EDTA清除率和同位素肾图测量总肾功能和分肾功能。梗阻肾排泄的钠量随着肾盂内最高压力升高而减少，随着平均动脉血压与肾盂内最高压力之间的差值增大而增加。浓缩能力越高，梗阻肾排泄的钠量越低。肾盂内最高压力与尿流之间存在高度显著的负相关，但平均动脉血压与肾盂内最高压力之间无相关性。因此，在强制利尿期间，浓缩能力正常的梗阻肾与对侧未梗阻肾的钠排泄量相同。另一方面，浓缩能力降低的梗阻肾排泄的钠相对较多。这可能是由于钠重吸收缺陷所致。
