Myakisheva S N, Linkova N S, Kozhevnikova E O, Polyakova V O, Ryzhak G A
Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dynamo, St. Petersburg 197110, Russian Federation, e-mail:
Saint-Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovskii pr., St. Petersburg 191036, Russian Federation.
Adv Gerontol. 2023;36(2):234-238.
Secretory phenotype associated with the aging (SASP) of chondrocytes forms the conditions for the musculoskeletal system diseases development, in particular, osteoarthritis (OA). The search for effective methods for OA treating is an urgent task of molecular gerontology. The purpose of this work is to characterize the SASP of chondrocytes and to conduct a comparative assessment of the effect of AED peptide and the cartilage polypeptide complex (CPC). It was found that chondrocyte's SASP is characterized by an increase of the synthesis of p16, p21, p53 pro-apoptotic proteins, TNF-α, IL-1α pro-inflammatory cytokines and a decrease of Sirt1synthesis. Peptides AED and CPC normalize the synthesis of molecules that form SASP of chondrocytes. This effect may explain their geroprotective effect and effectiveness in studies of various pathologies of the musculoskeletal system, including OA.
与软骨细胞衰老相关的分泌表型（SASP）为肌肉骨骼系统疾病，尤其是骨关节炎（OA）的发展创造了条件。寻找治疗OA的有效方法是分子老年医学的一项紧迫任务。这项工作的目的是表征软骨细胞的SASP，并对AED肽和软骨多肽复合物（CPC）的作用进行比较评估。研究发现，软骨细胞的SASP表现为促凋亡蛋白p16、p21、p53、促炎细胞因子TNF-α、IL-1α的合成增加，以及Sirt1合成减少。AED肽和CPC使形成软骨细胞SASP的分子合成正常化。这种作用可能解释了它们在包括OA在内的肌肉骨骼系统各种病理研究中的老年保护作用和有效性。
