Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.
Group of Peptide Regulation of Aging, Pavlov Institute of Physiology of Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
Cells. 2022 Dec 27;12(1):106. doi: 10.3390/cells12010106.
A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and myocardial infarction. The purpose of the review is to analyze the pool of signaling molecules that form SASP and inflammaging in cells of the cardiovascular system and to search for targets for the action of vasoprotective peptides. The SASP of cells of the cardiovascular system is characterized by a change in the synthesis of anti-proliferative proteins (p16, p19, p21, p38, p53), cytokines characteristic of inflammaging (IL-1α,β, IL-4, IL-6, IL-8, IL-18, TNFα, TGFβ1, NF-κB, MCP), matrix metalloproteinases, adhesion molecules, and sirtuins. It has been established that peptides are physiological regulators of body functions. Vasoprotective polypeptides (liraglutide, atrial natriuretic peptide, mimetics of relaxin, Ucn1, and adropin), KED tripeptide, and AEDR tetrapeptide regulate the synthesis of molecules involved in inflammaging and SASP-forming cells of the cardiovascular system. This indicates the prospects for the development of drugs based on peptides for the treatment of age-associated cardiovascular pathology.
衰老相关分泌表型 (SASP) 和衰老细胞的轻度炎症反应特征（炎症衰老）是心血管疾病发展的条件：动脉粥样硬化、冠心病和心肌梗死。本综述的目的是分析形成心血管系统细胞 SASP 和炎症衰老的信号分子库，并寻找血管保护肽作用的靶点。心血管系统细胞的 SASP 表现为抗增殖蛋白（p16、p19、p21、p38、p53）、炎症衰老特征性细胞因子（IL-1α、β、IL-4、IL-6、IL-8、IL-18、TNFα、TGFβ1、NF-κB、MCP）、基质金属蛋白酶、黏附分子和沉默调节蛋白合成的变化。已经证实肽是身体功能的生理调节剂。血管保护多肽（利拉鲁肽、心钠肽、松弛素模拟物、Ucn1 和 adropin）、KED 三肽和 AEDR 四肽调节参与炎症衰老和心血管系统 SASP 形成细胞的分子合成。这表明基于肽的药物在治疗与年龄相关的心血管病理学方面具有广阔的前景。
