The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan, China; Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan, China; Montreal Neurological Institute, McGill University, Montreal, QC, Canada, H3A 2B4.
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Department of Neurology, 363 Hospital, Chengdu 610041, Sichuan, China.
Epilepsy Behav. 2023 Aug;145:109323. doi: 10.1016/j.yebeh.2023.109323. Epub 2023 Jun 23.
Mozart's "Sonata for two pianos" (Köchel listing 448) has proven effective as music therapy for patients with epilepsy, but little is understood about the mechanism of which feature in it impacted therapeutic effect. This study explored whether tempo in that piece is important for its therapeutic effect.
We measured the effects of tempo in Mozart's sonata on clinical and electroencephalographic parameters of 147 patients with epilepsy who listened to the music at slow, original, or accelerated speed. As a control, patients listened to Haydn's Symphony no. 94 at original speed.
Listening to Mozart's piece at original speed significantly reduced the number of interictal epileptic discharges. It decreased beta power in the frontal, parietal, and occipital regions, suggesting increased auditory attention and reduced visual attention. It also decreased functional connectivity among frontal, parietal, temporal, and occipital brain regions, also suggesting increased auditory attention and reduced visual attention. No such effects were observed after patients listened to the slow or fast version of Mozart's piece, or to Haydn's symphony at normal speed.
These results suggest that Mozart's "Sonata for two pianos" may exert therapeutic effects by regulating attention when played at its original tempo, but not slower or faster. These findings may help guide the design and optimization of music therapy against epilepsy.
莫扎特的《双钢琴奏鸣曲》（Köchel 编号 448）已被证明对癫痫患者的音乐疗法有效，但对于其哪一特征对治疗效果有影响的机制知之甚少。本研究探讨了该曲的速度是否对其治疗效果重要。
我们测量了 147 名癫痫患者以慢、原速和加速速度聆听莫扎特奏鸣曲时，速度对临床和脑电图参数的影响。作为对照，患者以原速聆听海顿的第 94 交响曲。
以原速聆听莫扎特的作品显著减少了癫痫发作间期放电的次数。它降低了额叶、顶叶和枕叶的β功率，表明听觉注意力增加，视觉注意力减少。它还降低了额叶、顶叶、颞叶和枕叶脑区之间的功能连接，也表明听觉注意力增加，视觉注意力减少。患者聆听莫扎特作品的慢或快版本，或海顿交响曲以正常速度时，未观察到这种影响。
这些结果表明，莫扎特的《双钢琴奏鸣曲》以原速播放时，可能通过调节注意力发挥治疗作用，而不是更慢或更快的速度。这些发现可能有助于指导针对癫痫的音乐治疗的设计和优化。
