Lou R, Xu L P, Zhang X H, Liu K Y, Wang Y, Yan C H, Huang X J, Sun Y Q
Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing 100044, China.
Zhonghua Xue Ye Xue Za Zhi. 2023 Apr 14;44(4):289-294. doi: 10.3760/cma.j.issn.0253-2727.2023.04.005.
To explore the incidence and clinical characteristics of engraftment syndrome (ES) after syngeneic hematopoietic stem cell transplantation (syn-HSCT) in patients with hematological diseases. The clinical data of 21 patients who received syn-HSCT at People's Hospital of Peking University from January 1994 to May 2018 were retrospectively analyzed. Seven (33.3% ) of 21 patients developed ES. The onset of ES symptoms occurred at a median of 8 (range: 5-13) days after HSCT, and the diagnosis of ES occurred at a median of 10 (range: 7-14) days after HSCT. Steroids were administered immediately after the diagnosis of ES, the median time of symptom continuance was 2 (range: 1-5) days, and all patients showed complete resolution of ES symptoms. In the multivariate analysis, patients with acute myeloid leukemia and faster neutrophil reconstitution were the risk factors for ES (=15.298, 95% 1.486-157.501, =0.022, and =17.459, 95% 1.776-171.687, =0.014) . Meanwhile, there was no significant difference in the overall survival and disease-free survival between patients with ES and those without ES. A high incidence of ES was observed in syn-HSCT recipients. Moreover, the prognosis of ES was excellent.
探讨血液系统疾病患者同基因造血干细胞移植（syn-HSCT）后植入综合征（ES）的发生率及临床特征。回顾性分析1994年1月至2018年5月在北京大学人民医院接受syn-HSCT的21例患者的临床资料。21例患者中有7例（33.3%）发生ES。ES症状的中位出现时间为HSCT后8天（范围：5 - 13天），ES的诊断中位时间为HSCT后10天（范围：7 - 14天）。ES诊断后立即给予类固醇治疗，症状持续的中位时间为2天（范围：1 - 5天），所有患者ES症状均完全缓解。多因素分析显示，急性髓系白血病患者和中性粒细胞重建较快是ES的危险因素（=15.298，95% 1.486 - 157.501，=0.022，且=17.459，95% 1.776 - 171.687，=0.014）。同时，有ES患者与无ES患者的总生存和无病生存无显著差异。syn-HSCT受者中ES的发生率较高。此外，ES的预后良好。
