Kids Cancer Centre, Sydney Children's Hospital, Sydney Children's Hospitals Network, Randwick, NSW, Australia.
Clin Transplant. 2020 Jun;34(6):e13875. doi: 10.1111/ctr.13875. Epub 2020 Apr 27.
Engraftment syndrome (ES) is a poorly understood condition which continues to present a significant cause of morbidity following haematopoietic stem cell transplantation (HSCT). Yet a standard approach to diagnosis and treatment of ES remains elusive and has the potential to impact patient outcomes. A literature search was performed using the databases ProQuest Health, PubMed, Medline and Embase. Included studies were published in English from 2001-2019 that reported on engraftment syndrome following HSCT. Articles were organized by study design, ES diagnostic criteria, symptom classification and treatment. The review consolidated an array of literature relating to all types of HSCT. Timing of ES onset, risk factors and outcomes were compared within the literature. Signs and symptoms of reported ES were collated to establish a concise set of diagnostic criteria that can provide rapid recognition. The use of a standard approach to ES diagnosis has the potential to improve patient outcomes and provide a uniform approach to future research.
移植物抗宿主病（engraftment syndrome，ES）是一种发病机制尚不完全清楚的疾病，在造血干细胞移植（haematopoietic stem cell transplantation，HSCT）后仍然是发病率的重要原因。然而，针对 ES 的诊断和治疗标准方法仍难以捉摸，有可能影响患者的预后。使用 ProQuest Health、PubMed、Medline 和 Embase 数据库进行了文献检索。纳入的研究是 2001 年至 2019 年间发表的英文文章，报告了 HSCT 后的移植物抗宿主病。根据研究设计、ES 诊断标准、症状分类和治疗方法对文章进行了组织。本综述综合了与所有类型 HSCT 相关的一系列文献。对文献中 ES 发病时间、危险因素和结局进行了比较。收集了报道的 ES 的体征和症状，以建立一套简明的诊断标准，以便快速识别。采用标准的 ES 诊断方法有可能改善患者的预后，并为未来的研究提供统一的方法。
