1例恶性组织细胞增多症患者并发白吉利丝孢酵母肺炎。

Trichosporon beigelii pneumonia in a patient with malignant histiocytosis.

作者信息

Kobayashi M, Matsuoka T, Taguchi H, Moriki T, Enzan H, Hara H, Miyoshi I

出版信息

Jpn J Clin Oncol. 1986 Jun;16(2):167-74. doi: 10.1093/oxfordjournals.jjco.a039134.

DOI:10.1093/oxfordjournals.jjco.a039134

Abstract

A 30-year-old previously healthy housewife presented with bilateral pulmonary infiltrates. She was treated with various antibiotics but died with disseminated intravascular coagulation. Cultures of tracheal aspirates obtained prior to her death yielded Trichosporon beigelii. Postmortem examination revealed T. beigelii pneumonia with fungal dissemination in other organs. In addition, many organs were found to be infiltrated with atypical mononuclear cells which exhibited cytochemical properties of histiocytes. It was considered, therefore, that T. beigelii pneumonia developed on the basis of underlying malignant histiocytosis. T. beigelii in her lung sections was fluorescently stained with rabbit antiserum to the fungus isolated from the patient. This is the first report of Trichosporon beigelii pneumonia associated with malignant histiocytosis.

摘要

一名30岁既往健康的家庭主妇出现双侧肺部浸润。她接受了多种抗生素治疗，但最终死于弥散性血管内凝血。在她死亡前获取的气管吸出物培养物培养出白吉利丝孢酵母。尸检显示白吉利丝孢酵母肺炎伴真菌播散至其他器官。此外，发现许多器官被非典型单核细胞浸润，这些细胞表现出组织细胞的细胞化学特性。因此，认为白吉利丝孢酵母肺炎是在潜在的恶性组织细胞增多症基础上发生的。用从该患者分离出的真菌的兔抗血清对白吉利丝孢酵母在她的肺切片中进行荧光染色。这是首例与恶性组织细胞增多症相关的白吉利丝孢酵母肺炎报告。