Labiris, Brussels, Belgium.
Université Libre de Bruxelles, Brussels, Belgium.
Yeast. 2024 Apr;41(4):207-221. doi: 10.1002/yea.3885. Epub 2023 Jun 25.
Nitrogen catabolite repression (NCR) is a means for yeast to adapt its transcriptome to changing nitrogen sources in its environment. In conditions of derepression (under poor nitrogen conditions, upon rapamycin treatment, or when glutamine production is inhibited), two transcriptional activators of the GATA family are recruited to NCR-sensitive promoters and activate transcription of NCR-sensitive genes. Earlier observations have involved the Spt-Ada-Gcn5 acetyltransferase (SAGA) chromatin remodeling complex in these transcriptional regulations. In this report, we provide an illustration of the varying NCR-sensitive responses and question whether differing SAGA recruitment could explain this diversity of responses.
氮分解代谢物阻遏（NCR）是酵母适应其环境中氮源变化的一种手段。在去阻遏条件下（在氮源匮乏、雷帕霉素处理或谷氨酰胺生成受到抑制时），两种 GATA 家族转录激活因子被募集到 NCR 敏感启动子上，并激活 NCR 敏感基因的转录。早期的研究涉及 Spt-Ada-Gcn5 乙酰转移酶（SAGA）染色质重塑复合物在这些转录调控中的作用。在本报告中，我们说明了不同的 NCR 敏感反应，并质疑是否不同的 SAGA 募集可以解释这种反应的多样性。
