• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过抑制 Twist1，LY-290181 对乳腺癌细胞系产生抗迁移和抗侵袭作用。

Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1.

机构信息

College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.

出版信息

BMB Rep. 2023 Jul;56(7):410-415. doi: 10.5483/BMBRep.2023-0011.

DOI:10.5483/BMBRep.2023-0011
PMID:37357535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10390291/
Abstract

Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers. [BMB Reports 2023; 56(7): 410-415].

摘要

乳腺癌已成为全球女性最常见的癌症。在乳腺癌中，转移性乳腺癌与最高的死亡率相关。Twist1 是一种上皮-间充质转化调节转录因子，已知可促进乳腺癌细胞浸润转移部位。因此，靶向 Twist1 开发抗癌药物可能是一种有价值的策略。在这项研究中，LY-290181 呈剂量依赖性抑制乳腺癌细胞系的迁移、侵袭和多细胞肿瘤球体侵袭。LY-290181 的这些抗癌作用是通过下调 Twist1 蛋白水平介导的。LY-290181 抑制细胞外信号调节激酶和 c-Jun N-末端激酶信号通路。因此，我们的研究结果表明，LY-290181 可能成为未来针对转移性癌症的抗癌药物研发的基础。[BMB 报告 2023；56(7): 410-415]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/91427453e08d/bmb-56-7-410-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/a2dea7e79f9f/bmb-56-7-410-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/db4eed915b5e/bmb-56-7-410-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/1faabf49d51d/bmb-56-7-410-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/91427453e08d/bmb-56-7-410-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/a2dea7e79f9f/bmb-56-7-410-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/db4eed915b5e/bmb-56-7-410-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/1faabf49d51d/bmb-56-7-410-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b69/10390291/91427453e08d/bmb-56-7-410-f4.jpg

相似文献

1
Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1.通过抑制 Twist1，LY-290181 对乳腺癌细胞系产生抗迁移和抗侵袭作用。
BMB Rep. 2023 Jul;56(7):410-415. doi: 10.5483/BMBRep.2023-0011.
2
Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition.百里醌通过下调TWIST1表达以减少上皮-间质转化来抑制癌症转移。
Oncotarget. 2015 Aug 14;6(23):19580-91. doi: 10.18632/oncotarget.3973.
3
The Small C-terminal Domain Phosphatase 1 Inhibits Cancer Cell Migration and Invasion by Dephosphorylating Ser(P)68-Twist1 to Accelerate Twist1 Protein Degradation.小C末端结构域磷酸酶1通过去磷酸化Ser(P)68-Twist1来加速Twist1蛋白降解，从而抑制癌细胞的迁移和侵袭。
J Biol Chem. 2016 May 27;291(22):11518-28. doi: 10.1074/jbc.M116.721795. Epub 2016 Mar 14.
4
Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma.与Twist1相关的miR-26b-5p通过靶向SMAD1抑制肝细胞癌中的上皮-间质转化、迁移和侵袭。
Oncotarget. 2016 Apr 26;7(17):24383-401. doi: 10.18632/oncotarget.8328.
5
Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression.Twist1 通过沉默Foxa1 的表达促进乳腺癌的侵袭和转移。
Oncogene. 2017 Feb 23;36(8):1157-1166. doi: 10.1038/onc.2016.286. Epub 2016 Aug 15.
6
Role of pelitinib in the regulation of migration and invasion of hepatocellular carcinoma cells via inhibition of Twist1.培利替尼通过抑制 Twist1 调节肝癌细胞迁移和侵袭的作用。
BMC Cancer. 2023 Jul 27;23(1):703. doi: 10.1186/s12885-023-11217-2.
7
miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1.miR-720 通过靶向 TWIST1 抑制乳腺癌中的肿瘤侵袭和迁移。
Carcinogenesis. 2014 Feb;35(2):469-78. doi: 10.1093/carcin/bgt330. Epub 2013 Oct 1.
8
TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin α5 pathway.TFPI2 通过抑制 TWIST-整合素 α5 通路抑制乳腺癌进展。
Mol Med. 2020 Apr 5;26(1):27. doi: 10.1186/s10020-020-00158-2.
9
Anti-Cancer Effects of Glaucarubinone in the Hepatocellular Carcinoma Cell Line Huh7 via Regulation of the Epithelial-To-Mesenchymal Transition-Associated Transcription Factor Twist1.通过调控上皮间质转化相关转录因子 Twist1 发挥抗肝癌细胞系 Huh7 作用的角鲨烯酮
Int J Mol Sci. 2021 Feb 8;22(4):1700. doi: 10.3390/ijms22041700.
10
Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein.三结构域蛋白 28（TRIM28）通过稳定 TWIST1 蛋白促进乳腺癌转移。
Sci Rep. 2016 Jul 14;6:29822. doi: 10.1038/srep29822.

本文引用的文献

1
Metastasis and MAPK Pathways.转移和 MAPK 通路。
Int J Mol Sci. 2022 Mar 31;23(7):3847. doi: 10.3390/ijms23073847.
2
The Post-Translational Regulation of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis.癌症转移中上皮-间质转化诱导转录因子的翻译后调控
Int J Mol Sci. 2021 Mar 30;22(7):3591. doi: 10.3390/ijms22073591.
3
Triple-negative breast cancer molecular subtyping and treatment progress.三阴性乳腺癌分子分型及治疗进展。
Breast Cancer Res. 2020 Jun 9;22(1):61. doi: 10.1186/s13058-020-01296-5.
4
Epithelial-Mesenchymal Transition in Cancer: A Historical Overview.癌症中的上皮-间质转化：历史概述
Transl Oncol. 2020 Jun;13(6):100773. doi: 10.1016/j.tranon.2020.100773. Epub 2020 Apr 22.
5
Expression and clinical significance of MAPK and EGFR in triple-negative breast cancer.丝裂原活化蛋白激酶（MAPK）和表皮生长因子受体（EGFR）在三阴性乳腺癌中的表达及临床意义
Oncol Lett. 2020 Mar;19(3):1842-1848. doi: 10.3892/ol.2020.11274. Epub 2020 Jan 9.
6
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.作为潜在的肿瘤血管破坏剂的 LY290181 的新型萘并吡喃类似物。
Eur J Med Chem. 2019 Feb 1;163:160-168. doi: 10.1016/j.ejmech.2018.11.055. Epub 2018 Nov 23.
7
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
8
Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review).肿瘤发生中上皮-间充质转化的分子调控（综述）。
Int J Mol Med. 2018 Mar;41(3):1187-1200. doi: 10.3892/ijmm.2017.3320. Epub 2017 Dec 13.
9
Multiple biological functions of Twist1 in various cancers.Twist1在多种癌症中的多种生物学功能。
Oncotarget. 2017 Mar 21;8(12):20380-20393. doi: 10.18632/oncotarget.14608.
10
3D tumor spheroids: an overview on the tools and techniques used for their analysis.3D 肿瘤球体：用于分析它们的工具和技术概述。
Biotechnol Adv. 2016 Dec;34(8):1427-1441. doi: 10.1016/j.biotechadv.2016.11.002. Epub 2016 Nov 11.